JACI: New gene regulates the occurrence of asthma.

AUGUST 21, 2020 /--- In a recent study, researchers at Mount Sinai, N.Y., identified the main regulatory genes for asthma, providing new avenues for asthma research and the development of new therapies.
after identifying the genetic characteristics of mild, moderate, and severe persistent asthma, the researchers used probability causality to identify the main regulatory gene and validated its results in a separate queue.
researchers identified a common primary regulatory gene (FOXJ1) for asthma of varying severity and age.
primary regulatory gene for severe persistent asthma in children (LRRC23, TMEM231, CAPS, PTPRC FYB);
identified primary regulatory factors regulate the expression of downstream genes that regulate eyelash function and inflammatory responses to affect the final symptoms of asthma.
(Photo: www.pixabay.com) The study recruited 156 children with severe persistent asthma and control, and performed genetic transcriptomic analysis.
, the authors used a web-based probability causal approach to identify severe asthma genes and their main regulatory factors.
then used the same method in a separate queue of 190 adults with mild/moderate asthma and control groups to identify the genes for mild/moderate asthma and their main regulatory factors.
then compared and analyzed the primary regulatory genes, and then validated the tests in independent children with severe asthma (n s 21) and mild/moderate asthma (n s 154).
, a common disease that affects people of all ages around the world," said Dr. Supinda Bunyavanich, a researcher at Mount Sinai in The Sundial.
We looked at nasal tissue samples in children and adults with varying degrees of asthma, not only to identify mild, moderate, and severe asthma, but also to try to find the main regulatory genes that regulate the underlying biological processes of asthma, such as inflammatory responses and fibre function.
the main regulatory factors we identified provide a new way to explore the mechanisms of asthma and new therapies.
.com Source: Researchers identify master regulator genes of asthma Original source: Anh N. Do et al, Network study of nasal transcriptome profiles revealsses master of genes of asthma, Journal of Allergy and Clinical Immunology (2020). DOI: 10.1016/j.jaci.2020.07.006.