JACC: Revealing the mystery that biostents increase the risk of heart attack.

Biodegradable stents (biodegradable stents) are considered the ideal way to treat narrowing of coronary blood vessels. But so far, instead of dissolving satisfactorily, these biostents can cause a second heart attack more frequently than a metal stent. In a new study, researchers from the Cardiovascular Medicine Department at the University Hospital of Bern in Switzerland solved the puzzle. The findings were published in the November 2017 issue of the Journal of The American College of Cardiology under the title "Mechanisms of the Very Late Bioresable ScaffoldThrombosis".
since the first successful use of the air bag catheter in 1977, scientists around the world have been looking for the ideal stent to treat narrowing of coronary blood vessels. There is high hopes for a stent made of lactic acid, which was approved for sale in 2011, and which will dissolve completely within three to four years. However, studies conducted this year showed that the biostent did not meet expectations and even increased the risk of heart attacks again in the medium term. Now, the researchers are studying why it's like this.
when a biostent makes you sick
for the treatment of a biostent, no foreign objects remain in the coronary blood vessels, and it was initially hoped that coronary vascular wall inflammation would not occur frequently. Coronary blood vessels should regenerate themselves. However, most recent studies on stents have shown that biostents cause significantly more complications than usual metal stents, especially more than a year after stent implantation. So a few weeks ago, the bio-bracket manufacturer pulled the product out of the global market.
at first, it was not clear why complications alysation alyses. Now, the researchers, led by cardiologist Professor Lorenz R?ber. have discovered the cause. They worked with universities in Europe and Asia to study 36 patients who suffered from bioscant blockage after receiving implants for more than a year. This is only detectable through high-resolution imaging technology called optical coherent tomography. This technique provides approximate microscopic images from inside the blocked biological stent."These findings are startling, " says
. Although the biosed the stent properly, we realized that the stent fragments would invade the inside of the coronal blood vessels. "In fact, the role of this biostent fits the design goal: it breaks down into individual fragments." However, if these fragments do not fully enter the walls of the coronary arteries, they can enter the bloodstream, potentially leading to the formation of dangerous blood clots, which can then lead to a heart attack. "
blood thinnerist is critical
explains R?ber. "As a direct consequence of these findings, we recommend that our patients who receive biostent implants continue to take two blood thinners. This take lasts 3 to 4 years, not the usual 1 year. In this way, we are protected from unexpected biosor plugs. "Where
the biostent?
the discovery of this study also provides clues to the key features of subsequent biostent models. Thinner brackets and faster dissolution will be important improvements to solve current problems. Under the leadership of Professor Stephan Windecker, Director of Cardiovascular Medicine at the University Hospital of Bern, a team of the European Society of Cardiology recently issued guidelines on this (European Heart Journal, 7 October 2015, doi:10.1093/eurheartj/ehv203).
.