J Virol: Scientists find new targets to effectively protect against viral infections that induce damage to the body

2020 May 17 News /BioValleyBIOON / - When the body such as the face of high culture or nutritional deficiencies such as pressure conditions, the cells will produce and against the same large molecular structure of a viral infection, a few days ago, an article published in the international Journal ofJournalofVirologyresearch report, scientists from the University of Toledo and other institutions through the study said, when identifying new anti virus targets and against a variety of viral infections of immune regulation midnight, the association has perhaps a very promising targetSource: DanielMiller, TheUniversityofToledoresearchers MalathiKrishnamurthy represented, according to the current trends COVID-19, and by enhancing the body's own immune response and blocking perhaps the proliferation of lethal virus a potential strategy is to protect people from infection, scientists have an urgent need to identify new drugs and new drug targetsFor this study, the researchers revealed how the body's cells use special platforms A during normal pressure generated to help protect against virus infection, these new targets or the development of new therapies to help the body resist the severe damage caused by harmful virusesunderstand the molecular mechanism of the body's self-protection is also crucial for the development of novel therapies against a variety of viral infections, current antiviral therapy will be targeting the replication of virus or viral proteins, but higher viral the mutation rate often lead to drug resistance, therefore, to identify relevant studies from a variety of common virus against the host defense pathways or to help develop novel therapies to treat a range of viral diseases, including SARS-CoV-2 and so onthis study, the researchers revealed that when present in a cell where one named RNaseL (RNase L) is turned enzymes expressed in virus-infected cells in the body of ambient pressure generating a plurality of types of proteins and RNAs compositions molecular mechanisms (stress particles)During viral infection, a double-stranded RNA (dsRNA) molecules will be generated to alert the infected host cells to activate the immune pathwaythe body perceives these particular cell virus-infected cells to very specific dsRNAs, to produce a compound named interferon to protect the body and to remove the virus infection; The interferon can activate RNaseL, RNaseL will It is generated during activation of the expression of viral infection of small molecules, which when activated will generate a dsRNA more, thereby generating more interferon to remove the virusRNaseL addition, a variety of other proteins in the cell can modulate the host response to viral infection, and in a timely and coordinated response essential for expression against viral infectioncoping with conventional pressure body except that the pressure of the particle generated during viral infection can be adjusted in a more efficient and rapid reaction of the body to increase the production of interferon, so as to effectively remove the virus; final study He said that many viruses can adapt and evade the host's own immune response pathway, so the latter researchers also need more in-depth study of specific targets had sought help develop against harmful virus-induced severe damage to the body of the new therapy(Biovalley Bioon.com) Original source:PraveenManivannan, MohammadAdnanSiddiqui, KrishnamurthyMalathiRNaseLamplifiesinterferonsignalingbyinducingPKR-mediatedantiviralstressgranules,JournalofVirology < br /> (2020) .doi: 10.1128 / JVI.00205-20