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J Thromb Haemost: Thrombomodulin (THBD) Gene Variation and Thrombosis Risk

 Last Update: 2022-01-21
 Source: Internet
 Author: User

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Thrombomodulin (TM) was discovered in the 1980s when it was recognized that zymogen protein C (PC) is converted to activated protein C (APC) by thrombin
.

The PC anticoagulation system plays a key role in regulating hemostasis

thrombus

The aim of this study was to determine the risk of thrombosis in individuals with rare and common THBD variants in a large middle-aged and elderly population
.

Qualified mutational analysis was performed on the THBD exome sequences of 28,794 subjects (born 1923-1950, 60% female) who participated in the Malmö Diet and Cancer Study (1991-1996)
.

Patients were followed from baseline until the first occurrence of VTE, death, or 2018

We found that a single common coding mutation, rs1042579, was not associated with VTE events
.

Sixteen rare mutations were classified as eligible and included in the fold analysis

CONCLUSIONS: Rare eligible THBD mutations are associated with VTE, suggesting that rare variants in THBD contribute to the development of VTE
.

Rare eligible THBD mutations are associated with VTE, suggesting that rare variants in THBD contribute to the development of VTE
.

Original source:

Eric Manderstedt.

et al.
Thrombomodulin (THBD) gene variants and thrombotic risk in a population-based cohort study .

Original Source: Thrombomodulin (THBD) gene variants and thrombotic risk in a population-based cohort study Leave a comment here

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