J Thromb Haemost: Retinal vascular blockage of adult hereditary or obtainable thrombosis tendencies.

Blocked blood vessels in the retina are the main cause of blindness.
retinal arterial closure (RAO) and retinal venous blockage (RVO) are associated with high coagulation.
, however, it is not clear that these patients have a burden of thrombosis.
Recently, a study published in Journal of Thrombosis and Haemostasis, the authoritative journal of thrombosis and clotting disease, aims to assess the prevalence of hereditary or inherited thrombosis tendencies in adults with RAO or RVO through systematic review and meta-analysis of the literature.
researchers systematically searched Pubmed and EMBASE from the database to February 29, 2020.
all adult patients with RAO or RVO reported coagulation factor V Leiden (FVL) and coagulant enzymatic (F-II) G20210A mutations, MTHFR C677T and PAI 4G polymorphism, anticoagulant Studies of enzyme III (AT-III), protein C (PC) and protein S (PS) inactivity, hyperisocysteineemia, and antiphospholipid (APL) antibody prevalence were included in the analysis, and the combined prevalence and 95% confidence interval (CI) were calculated.
the analysis included 95 studies in which 6% (95%CI: 5-8%) and 3% (95%CI:2-4%) had FVL and F-II mutations, compared with less than 2% of patients with AT-III, PC and PS inactivity.
13% (95%CI:10-17%) and 23% (95%CI:16-31%) of patients with RVO observed MTHFR C677T and PAI 4G pure polymorphism, respectively;
similar results were observed in RAO patients, the researchers said.
, the prevalence of hereditary or accessative thrombosis in patients with retinal vascular embolism was similar compared to that of healthy subjects.
these results do not support routine screening of patients with RAO or RVO for thrombosis tendencies.
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