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J Rheumatol: Neurophysiological and immunological characteristics of peripheral nervous system intheiogenic syndrome

 Last Update: 2020-05-29
 Source: Internet
 Author: User

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The purpose of this study was to assess the prevalence, type and association between the presence of autonobodies and the progression of neuropathy in patients with primary dryness syndrome (
pSS)conducted a comprehensive neuroandaphysiological examination of61patients withpSS, as well asimmune, including rheumatology factors (
RF) and autoimmune antibodies such as antinuclear antibodies (
ANA), anti-
-ro/SSa, and anti-
La/SSB antibodies 39 patients (
63.9 %) experienced axon loss or demyelination 29 subjects (
47.5 %) met the clinical and electrophysiological criteria for axon-based peripheral neuropathy In patients with normal neuroconduction studies, serum resistance to and anti-
-La antibodies are more common at the same time Most patients with axonal neuropathy are only positive for anti-
-Ro (
p 0.05 ) The presence of RF is associated with several electro-
diagnostic signs of demyelinating (
p 0.01 ) ANA titer display is not independently associated with neuropathy peripheral neuropathy is a common complication of primary dryness syndrome Compared to anti-
-Ro and anti-
La antibodies at the same time, only anti-
-Ro serological lygo were associated with an increased risk of axial neuropathy RF positive may lead to demyelination

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