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Given that insulin resistance (IR) is common in patients with systemic lupus (SLE) andrheumatoid arthritis(RA), the study aims to determine whether ir sexist between the two diseases existsthe cross-sectional study included 413 non-
diabetessubjects, 186 SLE patients, and 227 RA patientsGlucose, insulin and C peptide serum levels and IR were studied through steady-state model evaluation (HOMA2)Multifactor regression analysis assessed the difference sie rating of IR between SLE patients and RA patients, and determined whether IR risk factors or disease-related characteristics in both populations were related to IR differencesafter multi-factor analysis, compared to SLE patients, insulin: C peptide mol ratio increased (beta coefficient 0.009 (95% CI 0.005-0.014), p-0.000)After multivariate analysis, it was found that THE HOMA2 index associated with insulin sensitivity in RA patients was lower (HOMA2-S% beta coefficient -27 -95% CI -46-9, p-0.004), while the cell function showed a higher IR index (HOMA2-B% beta coefficient 38,95% CI 23-52, p.000)More RA patients who met the IR definition than SLE (ratio 2.15 (95% CI 1.25-3.69), p-0.005)In both diseases, the IR factor has the same magnitude effect on the IR indexhas lower IR sensitivity and higher beta cell function compared to Patients with SLEIn SLE and RA, the fact that traditional IR factors have an equal effect on IR supports the argument that these differences are related to the disease itself
