J Neurophrin: HLA and KILLER cell immunoglobulin receptor (KIRs) genotypes in patients with acute ischemic stroke

In humans, the main components of natural killer (NK) and T-cell target identification depend on the monitoring of human leukocyte antigen (HLA) Class I molecules by the killer immunoglobulin receptor (KIR)The purpose of this study is to understand the immunological genetic background of acute ischemic stroke susceptibility to the frequency of the KIR gene and HLA allelegenotypes were performed on subjects with acute ischemic stroke and those without stroke to determine the presence of the KIR gene and the three main KIR ligand groups, hlA-B and HLA-A sites HLA-C1, HLA-C2 and HLA-Bw4results, patients with acute ischemic stroke were recruited continuously between November 2013 and February 2016As a healthy control, we recruited subjects who did not have acute ischemic strokeCompared to the control group, subjects with acute ischemic stroke showed higher frequencies of 2DL3, 2DL5B, 2DS2 and 2DS4 KIR genes, and lower HLA-B-Bw4I allelesSubjects without acute ischemic stroke showed higher frequency of interaction between KIR 2DS2 and HLAC2We also observed higher frequencies of the 2DL3 and 2 DL4 KIR genes in atherosclerosis (LAAS) subtypesMultiple logic regression analysis shows that HLA-B-Bw4I stroke has protective effect, and KIR 2DL2 has interaction with HLAC1 and 2DS2-HLAC2, and has harmful effecton on the interaction between 2DL2-HLA-C1_A, we found that the findings of activating the KIR gene more frequently appeared to be consistent with previously reported findings in patients with coronary artery syndromeThis higher frequency of the "pro-inflammatory" gene in patients with ischemic stroke can also explain immunoinflammatory activation during the acute stage of stroke