J Natl Cancer Inst: How do you eat aspirin, when do you start eating it, and how long do you eat it to prevent colorectal cancer?

The world faces a heavy burden of colorectal cancer, which accounts for 10 per cent of newly diagnosed cancer cases and contributes 9 per cent of cancer-related deaths.
aspirin is the most promising chemical prevention drug for colorectal cancer.
, however, previous epidemiological and interventional studies have failed to isolate the independent effects of aspirin in the chemical prevention of colorectal cancer.
study analyzed indicators of chemical prevention of colorectal cancer based on time in the Nurses' Health Study and the Health Professional Follow-up Study.
Taking into account that it usually takes at least 10 years for new adenomas to progress into colorectal cancer, the researchers used 10 years as a dividing line to target exposure as the cumulative average dose and total duration of aspirin 10 years ago (long term) and 10 years (short term) before follow-up began.
Cox model was used to estimate the risk ratio (HR) and 95% confidence interval (CI) for exposure and colorectal cancer.
before follow-up, aspirin had been in use for more than 10 years (HR 0.88, 95% CI 0.83 to 0.94 for each additional 5 years) and for just 10 years (HR 0.90, 95% CI 0.84 to 0.96) is equally important in the chemical prevention of colorectal cancer, but it will take more than 5 years to demonstrate the prevention effect of colorectal cancer in the near future.
In long-term patients, aspirin is not dose-dependent on colorectal cancer prevention; compared to the standard (325 mg)-dose tablets/week; aspirin dose is 0.5-lt;1.5, 1.5-lt. HR at 5 and 5 tablets/week was 0.78 (95% CI 0.6 3 to 0.98), 0.81 (0.72 to 0.91) and 0.74 (0.6 4 to 0.86).
, however, in the short-term patient queue, aspirin has a certain dose dependence on the prevention effect of colorectal cancer (HR at the above three dose levels is 0.91 (0.79 to 1.06), 0.87 (0.77 to 0.98) and 0.76 (0.64 to 0.91) respectively).
all, aspirin needs to be taken continuously for at least 6-10 years to have a significant effect on colorectal cancer prevention, most notably for 10 years.
long-term use and use over the past 10 years were independently associated with reduced risk of colorectal cancer, but long-term use required only a low dose for clinical benefits.