J Hepatol: Long Run Activates Cancer Control Gene! Scientists have found that anti-cancer genes such as p53, which activate serotto cells, can significantly reduce the risk of liver cancer in mice, even without losing weight.

Recent research by the Australian National University showed that exercises such as long-distance running activate anti-cancer genes such as p53 in liver cells in mice, while improving insulin sensitivity and reducing liver damage, and that even if obese mice do not lose weight, the risk of liver cancer can be significantly reduced, the study was published in Journal of The Journal of HepatologyA large amount of informationliver cancer of various risk factors, hepatitis C is certainly occupying the first and second, respectively, and then the next number is obesityIn Europe and the United States, obesity can lead to 15-35% of all liver cancer, the reason is not surprising, fat liver can be too common, combined with viral hepatitis more dangerousand because there are no approved treatment drugs, fatty liver treatment or diet control, exercise-based, many studies have suggested to maintain good exercise habits, and liver cancer risk reductionBut there is still much to be filled with the specific mechanism behind thisthe Australian National University team's research is to further clarify the institutional problemsThe team used the obesity/diabetes model mice, and on that basis used chemical carcinogens to induce liver cancer, and the way the mice moved was the magic instrument in the picture above, the wheelit turns out that the mice are more enthusiastic than many people, running up to 40 kilometers a week on the wheel, even if it's fresh, and running an average of 20 kilometers a week..However, because it was an obese/diabetic model mouse, even the exercise group weighed more than 40 grams, making it a fat rat group in the rat worldSo some mice (Ren) don't lose easily, blame the genesthe team selected two time nodes, 12 weeks and 24 weeks, to analyze cell-level abnormalities before the cancer in the livers of mice and the incidence of liver cancer at 24 weeksAt 12 weeks, the results were unexpected, and the running wheel significantly improved blood sugar and insulin levels in the mice in the exercise group, and the fatty liver level was relatively lighterbut cell-level analysis is the larger discoveryThe team found that the proportion of liver cells in the liver of the atypical growth in the liver of the mice in the exercise group decreased significantly, while the expression levels of the hepatocellular p53 gene and the downstream anti-cancer gene p27 showed significant increasesthe proportion of cells that have embarked on cancerous decline, coupled with the role of the anti-cancer gene, the risk of liver cancer is naturally low In mice with obesity/diabetes models in this study, the incidence of liver cancer normally fed for 6 months reached 64%, but in the exercise group, the incidence was reduced to 15%! The contrast is too stark.. And the movement group mice liver nodules are significantly less this protective effect, really bar And to determine the source of this protective effect, the team conducted a separate set of experiments and found that if the weight of mice was controlled only through diet and not exercise, the incidence of liver cancer in obese/diabetic model mice would still be very high, so exercise was the real umbrella and at the mechanism level, in addition to the previously found p53 and p27 genes, the team further experiments also showed that the exercise effectively inhibited the JNK1 kinase-mediated injury after the excessive proliferation of liver cells, after all, the next step of excessive proliferation, may be cancer, so the impact of JNK1 is worth digging deep in the words of the paper's author, Geoffrey Farrell, that the mechanism behind exercise is clear in order to reproduce the "protective effects of exercise" through drug therapy in future clinical practice, reducing the incidence and riskiness of liver cancer and improving the prognosis of patients