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J Clin Oncol: Talimogene Laherparepvec combined with Pemumab for advanced melanoma

 Last Update: 2022-09-07
 Source: Internet
 Author: User

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In a phase Ib study, the combination of Talimogene Laherparepvec (T-VEC) and Pemumab has demonstrated acceptable safety and an encouraging complete response rate (CRR)

The study was a randomized, double-blind, multicenter, international Phase 3 trial evaluating the efficacy and safety

In the study, patients with melanoma who were not previously treated with anti-programmed death protein-1 antibodies in stage IIIB-IVM1c who were inoperable were randomly (1:1) assigned to either the T-VEC-Pemimab group or the placebo-Pemimab group

Overall, a total of 692 patients were randomly assigned to either the T-VEC-Pymumab group or the placebo-Pymumab group (346 patients in each group

The incidence of treatment-related adverse events in the T-VEC-Pymumab group and the placebo-Pymumab group ≥-3 was 20.

In summary, the T-VEC-Pemimab group did not significantly improve PFS or OS

Original source:

DJason A.

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