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J Clin Oncol: PI3Kδ/CK1ε dual inhibitor Umbralisib for the treatment of relapsed/refractory indolent lymphoma

 Last Update: 2021-03-20
 Source: Internet
 Author: User

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Phosphatidylinositol-3-kinase (PI3K) inhibitors have shown therapeutic activity in relapsed or refractory (R/R) indolent non-Hodgkin's lymphoma (iNHL).

Lymphoma Umbralisib is a dual inhibitor of PI3Kδ/CK1ε.

This phase IIb trial aims to evaluate the efficacy and safety of Umbralisib in patients with R/R iNHL.

This is a multi-cohort, open-label Phase IIb study that recruited 208 R/R marginal zone, follicular, or small lymphocytic lymphomas that had failed previous treatments (including ≥1 anti-CD20-based therapies) (MZL, FL, or SLL) Patients receive 800 mg of Umbralisib orally every day until disease progression, intolerable toxicity, or withdrawal from the study.

Index lesion size response

The median follow-up time was 27.

The total effective rate was 47.

DOR and PFS

53.

In summary, Umbralisib has achieved significant clinical activity in severely pretreated iNHL patients.

Umbralisib has achieved significant clinical activity in severely preconditioned iNHL patients.

Original source:

Fowler Nathan H, Samaniego Felipe, Jurczak Wojciech et al.

org/doi/full/10.
1200/JCO.
20.
03433" target="_blank" rel="noopener">Umbralisib, a Dual PI3Kδ / CK1ε Inhibitor in Patients With Relapsed or Refractory Indolent Lymphoma in this message

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