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J Clin Oncol: Imetelstat, a telomerase inhibitor, can effectively treat myelofibrosis!

 Last Update: 2021-06-28
 Source: Internet
 Author: User

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The clinical prognosis of myelofibrosis patients with relapse or JAKi refractory (R/R) after treatment with Janus-related kinase inhibitor (JAKi) is poor, and the overall survival rate (OS) is only 13-16 months

Imetelstat is a telomerase inhibitor Imetelstat is a telomerase inhibitor

The test patients were randomly divided into groups and received Imetelstat 9.

A: OS of all randomized patients; B: correlation between OS and myelofibrosis change or stability

Study enrollment ended early, and patients receiving 4.

At 24 weeks, the spleen remission rate and symptom remission rate were 10.

All in all, in this phase II trial of two doses of Imetelstat, patients with bad-risk JAKi-R/R myelofibrosis can get clinically beneficial symptoms from Imetelstat 9.

JAKi-R/R myelofibrosis patients with adverse risks can obtain clinically beneficial symptom relief from Imetelstat 9.

Original source:

John Mascarenhas, et al.

Multicenter Phase II Study of Two Doses of Imetelstat in Relapsed or Refractory Myelofibrosis

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