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J Clin Oncol: Bentuximab vedodin can significantly reduce the radiation dose of children with high-risk Hodgkin's lymphoma without affecting the efficacy

 Last Update: 2021-05-08
 Source: Internet
 Author: User

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Bentuximab vitoxin is an effective anti-CD30 antibody drug conjugate, which has been approved for the treatment of adult classic Hodgkin's lymphoma (HL).

Lymphoma in children

This open-label, single-arm, multi-center trial included patients (age ≤ 18 years) with stage IIB, IIIB, or IV classic HL.

Of the 77 patients who participated in the study, 27 (35%) achieved complete remission at ERA and did not receive radiation therapy.

In summary, the results of the study show that the integration of Bentuximab Vidotin into the first-line treatment of children with high-risk HL is highly tolerated by the children, which is conducive to significantly reducing the dose of radiotherapy and can be achieved Good curative effect.

Original source:

Monika L Metzger, et al.

ncbi.
nlm.
nih.
gov/33826362/" target="_blank" rel="noopener">Excellent Outcome for Pediatric Patients With High- Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation in this message

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