J Clin Oncol: According to the UGT1A1 genotype quantification of Iliticon can significantly improve the prognostic prognostics of patients with advanced rectal cancer

Based on urinary glycostic acid glucosalic acid transferase 1A1 (UGT1A1) genotype-differentiated iliticcon dose can improve pathological complete remission (pCR) rate.
the study, the researchers further studied the therapeutic effects of preoperative Iliticon combined with capentabin-based topical radiotherapy for advanced rectal cancer.
Research Process The study conducted in China in a randomized, open-label, multi-center Phase 3 trial to recruit patients with rectal adenocarcinoma with clinical T3-4 stages and/or lymph node metastasis (N-plus).
randomly assigned patients with UGT1A1 genotypes of 1 x 1 or 1 x 28 to the control group (basin radiotherapy s/capatham) or the experimental group (radiotherapy s/capathamin s/ili Tycon ( . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
end point is pCR.
the basic characteristics of patients recruited a total of 360 patients, of whom 356 were included in the intended treatment population (178 in each group).
rate was 87% and 88%, respectively, in the control and experimental groups, and 15% (27 cases) and 30% (53 cases, with a risk ratio of 1.96, p-0.001), respectively.
4 and 6 patients in the control group and the experimental group received complete clinical remission, respectively.
3/4 toxicity in 11 (6%) and 68 (38%) patients in the control group and the experimental group, respectively.
the most common 3/4 toxic reactions are le white blood cell reduction, neutral granulocyte reduction... Nebula Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medical and are not reproduced by any media, website or individual without authorization, and are authorized to be reproduced with the words "Source: Mets Medicine".
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