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In acute lymphoblastic leukemia (ALL), neurocognitive impairment is the most common consequence, with a higher-than-expected incidence of young survivors of acute lymphoblastic leukemia, including memory impairment in 13% of patients, executive dysfunction in 17-54% of patients, and attention deficits and difficulty
In one study, the research team constructed a single-subject GM network based on multiple morphological characteristics and multiple Euclidean distances, and applied graph theory analysis to study the connection topology of young survivors of acute lymphoblastic leukemia
Figure 1.
Figure 2.
Figure 3.
Young survivors of ALL exhibited network hyperconnectivity (A, interconnect links of red lines) and low connectivity (B, blue lines) compared to the healthy control group
Figure 5: Connection strength versus clinical variables (A1-A4, non-therapeutic time; B.
Compared to HC, young survivors exhibited significantly lower global clustering coefficients (p = 0.
Overall, studies have shown that young survivors of acute lymphoblastic leukemia have disrupted topological tissue in MBN, and these abnormal morphological connection patterns are evident at the
Original Source:
Zhuang Y, Qian L, Wu L, Chen L, He F, Zhang S, Cheung GL, Zhou F, Gong H.
