J bone miner res: obesity can affect vitamin D metabolism!

February 24, 2019 / BIOON / - a new study published in Journal of bone and mineral research confirms that vitamin D supplementation will weaken in the case of obesity, which reveals a biological mechanism behind this phenomenon Photo source: https://stock.tuchong.com the study found that the liver enzymes responsible for transforming vitamin D into 25 hydroxyvitamin D (ossifying diol) were low in obese mice, and 25 hydroxyvitamin D was the main form of vitamin D in the blood Therefore, for obese patients, the treatment of vitamin D deficiency with ossifying diol should be more effective than other forms of vitamin D "The amount of ossifying diol in the blood of obese patients is usually very low, which has been attributed to the binding of vitamin D by fat cells Now we propose a second, more biologically significant mechanism: Obesity reduces the liver's ability to convert vitamin D into 25 hydroxyvitamin D " Jeffrey Roizen, Ph.D., of the children's Hospital in Philadelphia, who led the study "Our findings suggest that obesity may affect the early activation of vitamin D, which suggests that the influence of obesity on liver has an important systemic effect on bone and mineral metabolism In addition, in the past, we always thought that too low vitamin D content led to obesity Our work shows that in fact, disease or pathological state (such as obesity) led to low vitamin D content " Reference: Jeffrey D Rozen et al, objective decisions hepatic 25 hydroxylase activity causing low serum 25 hydroxylvitamin D, Journal of bone and Mineral Research (2019) Doi: 10.1002/jbmr.3686