J bio Chem: breakthrough! Key ingredients in green tea and carrots can reverse Alzheimer's disease!

March 11, 2019 / Biovalley / researchers from the University of Southern California (USC) said that diets containing certain substances in green tea and carrots can reverse Alzheimer's like symptoms in mice that carry genetic mutations that should have developed Alzheimer's disease Photo source: Journal of biological chemistry researchers said the recent study published in Journal of biological chemistry was carried out in mice, but many findings from mice could not be successfully replicated in humans In any case, the study adds credibility to the idea that some ready-made, plant-based supplements may provide protection against human dementia "No one wants to spend 10-12 years waiting for a new drug to come to market You can change your diet today." Terrence Town, co-author of the study and professor of physiology and neuroscience at USC's Keck School of medicine, said "I find it very inspiring." In addition, the study suggests that combination therapy may be the best way to treat Alzheimer's In this study, the researchers found that a combination of two compounds can reverse Alzheimer's disease: epigallocatechin gallate (EGCG), a key component of green tea, and ferulic acid (FA) in crops such as carrots, potatoes, rice and wheat The researchers randomly divided 32 mice with Alzheimer's like symptoms into four groups, each with the same number of males and females For comparison, each group also contained the same number of healthy mice The researchers gave mice EGCG plus FA, EGCG, FA or placebo for three months The dose is 30 mg / kg body weight - it can be tolerated by the human body, or it can be obtained through a healthy diet or supplement Before and after the experiment, the researchers carried out a series of neuropsychological tests on mice, equivalent to human thinking and memory tests Of particular note is a Y-shaped maze, which tests the spatial working memory of mice through which humans find a way out of buildings Healthy mice instinctively explore each arm of the Y-maze, look for food or escape routes, and enter the three arms in order, rather than running randomly, but the sick mice can not complete these tests normally "Three months later, the combination therapy completely restored the working memory ability of mice and reversed the symptoms of Alzheimer's disease, and the performance of these mice was the same as that of normal mice." Said town So how does this therapy work? Town said one mechanism might be that these substances prevent amyloid precursor proteins from damaging to form beta amyloid, a protein rich in the brains of Alzheimer's patients In addition, these compounds appear to reduce neuroinflammation and oxidative stress in the brain - key pathological features of the brain in people with Alzheimer's disease Town said he and his lab will continue to explore the combination therapy, focusing on using plant-derived substances to inhibit the formation of beta amyloid plates Reference: Takashi Mori et al, combined treatment with the phenolics (−) - epiallocatecin-3-collate and hydraulic acid improvements combination and reduces Alzheimer like pathway in mice, Journal of Biological Chemistry (2018) Doi: 10.1074/jbc.ra118.004280