J Am Soc Nephrol: The American Society of Nephrology says less than six hours of sleep hurts the kidneys, and healthy kidneys require good sleep.

Chronic kidney disease (CKD) is a major health problem worldwide, and observational studies have shown that short sleep durations and poor sleep quality are associated with an increase in the risk of chronic kidney disease.
, however, due to a variety of possible conferring factors, it is difficult to clarify the exact nature of the relationship between sleep and chronic kidney disease.
many studies have found that sleep behavior is associated with cardiovascular disease and kidney function, but few have looked at the damage to kidney function caused by the length of sleep.
October 2020, researchers at Seoul University in South Korea published a research paper entitled: Short or Long Sleep Duration and CKD: A Mendelian Randomization Study in journal Journal of The American Society of Nephrology.
the study showed that short sleep durations (6-8 hours per day) or long sleep durations (9 hours per day≥ were associated with a higher prevalence of chronic kidney disease than moderate sleep time (6-8 hours per day).
risk scores for short sleep durations were significantly associated with chronic kidney disease, and these findings suggest that short sleep periods have significant adverse effects on kidney function.
clinicians can encourage patients to avoid short sleep behaviors to reduce the risk of chronic kidney disease.
team analysed data from participants aged 40-69 in the UK Biobank prospective queue, including 25,605 self-reported short sleep times (six hours per day), 404,550 self-reported sleep hours (6-8 hours per day) and 35,659 self-reported long-term sleep periods (≥9 hours per day).
team investigated the observational correlation between the length of sleep and stage 3-5 of chronic kidney disease and analyzed it through a logical regression analysis.
showed that both short sleep and long sleep duration were associated with a higher incidence of chronic kidney disease.
Randomization (MR) is the use of large-scale genomic association analysis (GWAS) data to clarify causality.
in short, Mendel randomization can prove a causal relationship between lifestyle factors for complex diseases by taking into account common genetic risks between genetic factors, often in the form of genetic risk scores.
Because genetics is fixed from birth and remains relatively stable throughout a person's life, Mendelsoption is less affected by reverse causation or mixing, so it can be clarified.
's team conducted a randomized analysis of 321,260 white British men, a genetic risk scoring analysis with single-sample Mendel randomization, and further verified the causal relationship between short sleep duration and chronic kidney disease through meta-analysis of chronic kidney disease results from the independent CKDGen Alliance genome-wide association study.
overall, the study showed that sleep duration has a significant effect on chronic kidney disease, and that too little and too much sleep can lead to kidney damage, and that healthy kidneys need good sleep.
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