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Author: Jeffrey R.
Although Ivermectin was originally used to treat river blindness (onchocerciasis), it was later found to be useful for the treatment of other human parasitic infections
Ivermectin is a miraculous drug that has been used to treat life-threatening and vision-threatening parasitic infections for more than 30 years
Some patients believe that ivermectin can cure their severe COVID-19 infection, thus delaying proper treatment
Although Ivermectin has changed the rules of the game for patients with certain infectious diseases, it cannot save patients from COVID-19 infection
Let me tell you a little story about the history of ivermectin
Ivermectin is commonly used to treat and control parasites in animals including horses
Development of ivermectin for animals
Ivermectin was first discovered in the veterinary drug screening project of Merck Pharmaceuticals in the 1970s
Merck cooperates with Kitasato Research Institute, a medical research institution in Japan
The research on abamectin lasted about 5 years
The compounds that make up ivermectin were first discovered in bacteria in the soil of a golf course in Japan
Development of ivermectin for human use
Early experiments by William Campbell of Merck and his team found that the drug is also effective against a human parasite that causes river blindness
River blindness, also known as onchocerciasis, is the second most preventable cause of blindness in the world
In 1982, Ivermectin was tested for the treatment of river blindness and was approved in 1987
In the 20 years of extensive work in the discovery, development and distribution of ivermectin, people's suffering from river blindness has been greatly reduced
Use the drug for other purposes
Infectious disease researchers often try to use antibiotics and other drugs to treat infections
For many years, Ivermectin has been approved for the treatment of river blindness and has also been proven to be very effective against other parasitic infections
.
This includes Strongyloidiasis, an intestinal roundworm infection that affects approximately 30 million to 100 million people worldwide
.
Another example is Amphotericin B, which was originally approved for the treatment of human yeast and mold infections
.
Researchers have found that amphotericin B can also effectively treat severe forms of leishmaniasis, a parasitic infection that is endemic in tropical and subtropical countries
.
Similarly, doxycycline is an antibiotic used for many human bacterial infections, such as pneumonia and Lyme disease
.
It was later found to be very effective in preventing and treating malaria
.
Ivermectin has been used to treat strongyloidiasis, an intestinal infection that can be life-threatening to people with weakened immune systems
.
Reuse of COVID-19 drugs
However, not every attempt to reuse drugs can achieve the desired results
.
At the beginning of the COVID-19 pandemic, scientists and doctors tried to find cheap drugs to treat and prevent COVID-19
.
Chloroquine and hydroxychloroquine are two of these drugs
.
They were chosen because of their possible antiviral effects in laboratory studies and the limited anecdotal case reports
.
However, large-scale clinical studies on these drugs for the treatment of COVID-19 have not brought any meaningful benefits
.
This is partly because the patient experiences severe toxic effects before the drug reaches a high dose sufficient to inhibit or kill the virus
.
Unfortunately, the lessons learned from these failed attempts have not been reflected on ivermectin
.
The false hope regarding the use of ivermectin to treat COVID-19 stems from a laboratory study in Australia in April 2020
.
Although the results of this study were widely disseminated, some scientists immediately aroused serious suspicions
.
The concentration of ivermectin they tested was 20 to 2000 times higher than the standard dose used to treat human parasitic infections
.
In fact, within a month of the paper’s publication, many other pharmaceutical experts confirmed their concerns
.
Such a high concentration of the drug may have obvious toxicity
.
Another frequently cited paper on the efficacy of ivermectin against COVID-19 was withdrawn in July 2021 after scientists discovered that the study had serious flaws
.
These deficiencies include incorrect statistical analysis, discrepancies between collected data and published results, duplicate patient records, and subjects who died before entering the study
.
Even more worrying is that at least two other frequently cited studies have raised serious concerns about scientific fraud
.
At the time of writing, two large randomized clinical trials have shown that the use of ivermectin for COVID-19 has no significant benefit
.
Well-known national and international health care organizations, including the World Health Organization, the Centers for Disease Control and Prevention, the National Institutes of Health, the Food and Drug Administration, and the American Academy of Infectious Diseases, have unanimously recommended not to use ivermectin to prevent or treat COVID-19 , Except in the context of clinical trials
.
Consequences of using ivermectin to treat COVID-19
Unfortunately, many organizations with suspicious intentions continue to promote the use of ivermectin for COVID-19, but this has not been confirmed
.
This led to a sharp increase in ivermectin prescriptions, and the US Poison Control Center received a large number of calls from ivermectin overdose
.
Many of the appeals were due to the intake of large amounts of veterinary products containing ivermectin-two deaths related to ivermectin overdose were reported in September 2021
.
If used correctly, ivermectin can prevent millions of potentially fatal and debilitating infectious diseases
.
This medicine can only be used to treat infections caused by parasites
.
It does not refer to prescriptions for parasites who want to extract money from desperate people during an epidemic
.
With this article, Jeffrey R.
Aeschlimann, associate professor of pharmacy at the University of Connecticut, sincerely hopes that this unfortunate and tragic chapter will end as soon as possible in this incredible story of life-saving drugs
.