Issue 22/2015 - The industrialization of chiral epichlorohydrin has made significant progress in the Chinese Academy of Sciences

Recently, the "new generation manufacturing process and industrial production technology of key intermediates of chiral epichlorohydrin drugs" cooperated by the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences and Shulan Jinma Chemical Co.
, Ltd.
passed the project acceptance
jointly organized by the Spring Branch of the President of the Chinese Academy of Sciences, the Department of Finance of Jilin Province and the Department of Science and Technology of Jilin Province.

The catalyst activity of this technology is 1~2 orders of magnitude higher than that of the general Jacobsen Salen-Co catalyst, and the catalyst dosage of 1 ton of optical pure epichlorohydrin for industrial production has been reduced from the original 25 kg to 0.
8 kg, and the catalyst consumption for the production of 1 ton of optical pure epichlorohydrin products has been reduced from 2500 yuan to 850 yuan
。 Due to the significant reduction in the amount of catalyst used in the new technology, it brings great convenience to product separation; The yield of optically pure epichlorohydrin reached more than 47%, which was 3%~4% higher than that of the original technology; In addition, chloroglycerin, a by-product of the new technology, is supplied directly as a raw material to the company for further conversion, so that there is almost no waste discharge
from the entire process.
Due to the improvement of the refining efficiency of the new technology, the monthly production capacity in the same production plant has been increased from 50 tons to 120 tons, the production efficiency has been greatly improved, and the energy consumption of tons of optical pure epichlorohydrin products has been reduced by more than
30%.
The catalyst synthesis cost is 36% lower than expected, and the catalyst production can be adjusted at any time according to the actual market demand, and the production cost of chiral epichlorohydrin is reduced by 25%.

In the process of industrial production of new technology, the product quality is stable, the chemical purity of the product is > 99%, and the optical purity is > 99%, which fully meets the requirements of
technical indicators.

Through the implementation of the project for more than two years, the domestic market share of chiral epichlorohydrin products produced by Shulan Jinma Chemical Co.
, Ltd.
has reached almost 100%, getting rid of foreign technology monopoly, creating an output value of 86 million yuan and profits and taxes of 12.
9 million yuan
.

(New)