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Let's take a look at the 6 major research advances in this field over the past year! The regeneration of islet β cells has always been a hot topic in the field of diabetes, especially for type 1 diabetes, islet β cell transplantation is considered to be the hope
of curing type 1 diabetes.
At the European Association for the Study of Diabetes (EASD) held from September 19 to 23, a special oral presentation on new advances in islet β cell regeneration was also set up, which covered 6 parts, from the progress of materials research, the proposal of new preparation protocols, solving the bottleneck of batch β cell sources, the survival of transplanted cells, monitoring the efficacy and other different perspectives, bringing us the progress of research in this field in the
past year.
6 major directions - new research, new ideas
The success of islet β cell transplantation depends on the number of viable and functional islet β cells, which are difficult to accurately estimate
with current methods.
Researchers from Western Sydney University have attempted to use microRNA as an alternative marker for the assessment of β cell function/death and assess its potential
to predict subsequent transplant function of islet transplant recipients.
Plasma samples were collected in recipients 1 h, 24 h (Edmonton, n=15), or 1 and 20 weeks (Chicago, n=18-23) before and after allogeneic human islet transplantation
.
A set of microRNAs associated with insulin gene transcription was measured using realtime qPCR
.
The results showed an increase
in overall abundance of 19 insulin transcripts, compared to pre-transplant levels, at 1 h post-transplant.
Highlight reviews
I Zhu Yu, chief physician of the Department of Endocrinology, Peking University People's Hospital
Islet β cell transplantation has always been a hot topic
in the field of diabetes treatment.
However, many important aspects related to transplantation prognosis, such as adequate IVA β cell preparation, effective infusion, and long-term survival, have not yet achieved fully satisfactory clinical goals
.
This year's EASD researchers in related fields have provided us with the results of cross-fusion between new materials science and medicine, continuously optimized the vectors in the β cell infusion process from the perspective of biomaterials, and provided solutions for the challenges caused by hypoxia, and the way in which β cells and mesenchymal stem cells are co-infused provides new possible directions
for future research in this field.
At the same time, the results of single-cell sequencing involving multiple populations by researchers reveal the important links, genes and interactions that play a regulatory role in the differentiation and development of human β cells, providing a basis
for the preparation of a large number of β cells in vitro.
There are also researchers who are concerned about maintaining the survival of transplanted cells, elaborating on the factors that may affect transplant survival from different perspectives and providing new ideas for predicting transplant prognosis
.
Advances in this area will undoubtedly bring hope for a cure for diabetes, especially type 1 diabetes, and we all look forward to this day as soon as possible!
This article is written by the review experts
Reference source:
com）.
