intracranial multiple meningocomy

Meningioma, which originated in the cobweb synocoscosincapof the membrane of the membrane,(
arachnoidal cap cell) and is a type ofcommon intracranial primary tumor, with an annual incidence of 5.5 per 100,000the autopsy found that theof meningioma accounted for50% of the, indicating that themajority of meningiomas inpatientsthe whole life of themaintain asymptomaticstate ; multiple meningioma (
m ultiple meningioma , MM ) refers to the simultaneous or non-simultaneous occurrence of two or more or more independent meningioma , accounts for only 10% of the total of meningioma less than MM is associated with mutations in NF2 , the mm mm that are not associated with the of NF2 may be the result of an occasional , , or family history, , or a single acontinuous spread of diffuse tumors there are two hypotheses about mm's pathological mechanism: the first hypothesis, based on the differences in histological and cytogenetics between different substantive meningiomas in the same patient, it is speculated that the tumor occurred independently ; Molecular genetic analysis and common of substantive meninoma NF2 gene mutations provide evidence for the second monoclonal origin hypothesis of Neurology and Neurosurgery, Clinical Hospital, University of Sao Paulo, Brazil, The study of the case data of the medical center of the medical center, such as Benedito Jamilson Arau and jo Pereira , summarizes the natural history of MM in conjunction with published literature results were published in the november 2018 W
orld
N eurosurg ery online study methods
21 (3.3%) of the 629 patients diagnosed with meningioma at the University Hospital of S?o Paulo between 2000 and 2014 were MM The author analyzed the clinical symptoms, neuroimaging performance, surgical records and tissue pathology characteristics of MM patients, including age, sex, family history, combined systemic malignancies, number and location of meningioma, number and scope of excision, histopathology classification and tumor classification, complementary treatment, follow-up time, tumor recurrence and mortality It was found that of the 21 MM (3.3%) patients, 16 were female and 5 were male, and the age was 31-82 years old, with an average age of 55.8 to 11.26 years A total of 58 meningiomas 39 were removed, with an average of 2 to 7 meningiomas per patient According to the 2007 WHO meningioma grading standard, 20 cases were WHO I and 1 case was WHO II 4 cases (19%) combined with other systemic tumors, including 2 cases of thyroid tumors, 1 case of breast tumor sympathical tumor and 1 case of gastrointestinal tumor the author also used the keyword "multiple meningioma", through Medline to search the Global Medical Center as of August 2018 published on THE MM literature, excluding clinical and neuroimaging data incomplete, follow-up less than 5 years of the paper, will meet the research criteria of 9 MM patients plus the above 21 cases, a total of 293 MM patients included in the analysis; The total number of meningiomas is 932, an average of 3.1 per patient Most tumors are located on the convex surface of the brain (653-74.5%), followed by the cranial base (220-25.1%) and the ventricle (45%-0.4%) The total number of tumor treatments was 429 (43.9%), including 338 surgical removals (78.8%) and 91 radiotherapy (21.2%) Of the 429 tumors, 303 were organized pathology results: 272 in WHO I (90.3%), 30.7% for the epithelial subtype of the meninges, 26 (8.1%) of THE WHO II class and 5 (1.6%) in THE WHO CLASS III Patients were followed by 11-35 years, with an average of 21.4 to 8.6 years Of the 397 tumors, 32 (8.07%) showed signs of tumor recurrence Of the 281 follow-up patients, only 10 died (3.4%) conclusion
the final authors concluded that MM is like a single meningioma, the vast majority of WHO I, located in the brain convex surface of the most seen; Of the MM patients in the study, 78.8 percent had surgery and 21.2 percent were radiation therapy It is worth noting that most tumors are small and asymptomatic, requiring treatment for less than half of MM patients (43.9%) The recurrence rate and mortality rate of MM patients were both low, which confirmed the benign biological behavior of the tumor.