Into the field of pharmaceutical separation and purification, explore the space worth exploring

Separation and purification is the core link in the production process of pharmaceutical preparations.
How to remove harmful substances or impurities in the target product while maintaining the activity of the target product is the key to separation and purification technology
.
In recent years, with the rapid development of China's pharmaceutical industry, how to economically and efficiently concentrate, separate and purify target biomolecules from complex components has become a major focus of many formulation companies
.
After years of scientific and technological development, a large number of new technologies and methods have emerged in the separation and purification of pharmaceuticals in China, such as macroporous resin adsorption, high-speed countercurrent chromatography separation technology, ultrafiltration membrane technology, etc.
, and many extraction, separation and purification technologies It has been developed and applied, and some new devices have also been born
.
Among them, the macroporous resin adsorption method is characterized by adsorption, through the combination of physical adsorption and molecular sieve to achieve separation and purification.
This method has stable physical and chemical properties, good selectivity, strong adsorption capacity, easy elution, recyclable use and The advantages of regeneration treatment, economy and environmental protection, and convenient formulation forming have been widely used in the purification and separation of natural medicines and Chinese medicine active ingredients, the purification of compound Chinese medicine preparations, and the removal of harmful impurities in recent years
.
However, the disadvantages of this method are small processing capacity, small production capacity, and large equipment investment
.
High-speed countercurrent chromatography separation technology is a separation and purification preparation technology that has attracted more attention in recent years.
In the pharmaceutical industry, it is maturely applied to the separation and purification of microbial fermentation active substances with a unique separation theory.
It can achieve better separation effects and purification The advantages of high preparation efficiency, low cost of operating consumables, great protection of active substances, high recovery rate, etc.
, are playing an increasingly important role
.
Ultrafiltration membrane technology is a new type of membrane separation technology that uses selective porous membranes as separators to allow a mixture of molecules of different particle sizes at the molecular level to pass through the membrane with a certain driving force such as pressure difference, concentration difference, and potential difference.
Selective separation technology can achieve the purpose of separation, concentration and purification
.
Generally speaking, traditional purification processes have many problems such as low extraction efficiency, high production costs, residual organic solvents, and complex and difficult process operations, which affect the quality of products
.
The ultrafiltration membrane technology can effectively purify the macromolecular substances in the mixed liquid
.
And at room temperature, the liquid has no phase change, the active ingredient is less damaged, the production efficiency is high, the energy saving and consumption reduction, the equipment investment cost and the operating cost are low.
It is generally regarded as a very promising purification and separation technology
.
However, the industry also pointed out that, on the whole, the application of new separation and purification technologies and equipment such as ultrafiltration membranes by pharmaceutical companies is not extensive enough, making the overall level of pharmaceutical separation and purification technology and product quality not high enough.
This is also an urgent need for industries in the field of separation and purification.
Enterprises strengthen independent innovation, improve the level of automatic production control, and better serve the pharmaceutical industry
.
It is understood that the current ultrafiltration membrane equipment on the market is mainly imported from Germany and other imported manufacturers.
Domestic companies are gradually catching up with imported companies in recent years.
Some of the powerful manufacturers have strengthened technological research and development capabilities, optimized process design, and improved after-sales service.
Constant efforts have been made in various aspects, focusing on the training of high-level talents, and many manufacturers have transformed from a single equipment supplier to a supplier that can provide overall solutions for membrane separation technology to further meet the experimental and production needs of different pharmaceutical customers
.
With the rapid development of China's pharmaceutical industry, it is expected that in the future, domestic manufacturers of ultrafiltration membrane equipment will have more room to explore
.