Studies have found that: intestinal microbial disorders lead to intestinal cancer

　　MEDICINE, Nov 22 (Xinhua) -- A recent study from the Department of Microbiology at the University of Coll?ge in France has shown that imbalances in the gut flora can promote the onset of colorectal cancer The authors found that transplanting fecal flora in colon cancer patients into mice would cause lesions and epigenetic changes in the development of malignant tumors The results were published in the latest pNAS issue -distributive colorectal cancer occurs due to complex interactions between individuals and their environment In adverse environments, changes in the genetic and epigenetic DNA of host cells can be triggered to promote the onset of prosoccur colorectal cancer previous studies have investigated the role of the microbiome as a medium for these interactions The results of mouse-based studies show that epigenetic mechanisms triggered by certain bacteria in the microbiome contribute to the occurrence or deterioration of proative colorectal cancer They then validated their findings in humans study, 136 mice were transplanted with fresh faeces from nine patients with distributive colorectal cancer or 9 patients without colon The authors then examined the colons of mice 7 and 14 weeks after transplantation The number and deterioration of abnormal reclusive lesions (or ACF, a type of precancerous lesions), microbial characteristics, and damage to colon DNA were also studied They also measured the animal's food intake, weight and blood index the link between fecal malnutrition (imbalance in the composition of gut bacteria) and genetic and epigenetic DNA markers in animal tissues has been confirmed by statistical tests Mice that received fresh feces from patients with diffuse colorectal cancer developed a presence known as abnormal reclusive (ACF), which is considered a type of precancerous lesions However, there were no significant genetic changes in colon tissue after verifying the link between flora disorders in the feces of patients with diffuse colorectal cancer, which is a fecal transplant donor, and DNA abnormalities (methylation), the authors hope to develop a simple, reusable blood test for early diagnosis of the of the intestines of asymptomatic patients this study showed that the microbiome of patients with distributive colorectal cancer induces precancerous colon lesions in animals through high lymline of a few genes Therefore, CMI and/or methylated bacteria can be used as diagnostic markers for such cancers Of course, these preliminary findings need to be evaluated and confirmed in clinical trials source: Gut microbiota an promote the onet of the colorectal cancer
original origin: Iradj Sobhani, Emma Bergten, S?verine Couffin, Aur?lien Amiot, Biba Nebbad, Caroline Barau, Nicola de Angeli, Sylvie Rabot, Florence Canoui-Poitrine, Denis Metivier, Thier P?dron, Khaar hay Khahazai, Philippe Colorectal cancer-aciated microbiota contribute to oncanigeneticig Proceeding of the National Academy of Sciences, 2019; 201912129 DOI: 10.1073/pna.191229116