International Network Disease Congress • Diabetes Forum Chinese medicine has entered the main position of diabetes prevention and control

"Attaching equal importance to traditional Chinese medicine and Western medicine is an important strategy and guideline for the prevention and treatment of diabetes in China, and the "National Guidelines for the Prevention and Treatment of Diabetes at the Grassroots Level (2022)" released this year has added a chapter

Recently, at the Diabetes Forum of the 18th International Conference on Network Diseases and the 9th Conference on Integrative Chinese and Western Medicine Vasculology held in Guangzhou, Professor Zhao Jiajun, chairman of the forum, chairman of the Endocrinology Professional Committee of the Chinese Medical Association, and president of Shandong Provincial Hospital, once again stressed that in recent years, Chinese medicine has achieved more and more evidence-based medical evidence support, and gradually entered the main position of diabetes prevention and control, playing an important role

Academician's speech

Academician Ning Guang

"Ruijin Hospital affiliated to Shanghai Jiao Tong University, as a third-class hospital, has always adhered to the principle of common development of traditional Chinese and Western medicine, and established a fine tradition

Academician Tong Xiaolin

"The series of innovative drugs developed under the guidance of network disease theory and its guidance have played a major role in major multi-system clinical diseases such as cardiovascular and cerebrovascular diseases, endocrinology, immunology, urinary and other major diseases and sudden respiratory public health events, and have achieved breakthrough results, making important contributions to promoting the development of Traditional Chinese medicine in China and significantly enhancing the international influence

Diabetes Forum Venue

As one of the core sub-forums of the International Conference on Network Disease, the Diabetes Forum focused on the theory of network disease to guide the treatment strategy of diabetes and the research progress of prescription drugs on the Internet for extensive exchange

The conference specially invited Professor Guo Lixin of the National Geriatrics Center of Beijing Hospital, Professor Li Xiaoying of Zhongshan Hospital Affiliated to Fudan University, Professor Xiao Xinhua of Peking Union Medical College Hospital, Professor Yan Li of Sun Yat-sen Memorial Hospital of Sun Yat-sen University as the academic session host, and many heavyweight experts in the field of endocrinology in China shared and analyzed in depth the current situation of diabetes diagnosis and treatment, the new version of diabetes prevention and treatment guidelines and the diagnosis and treatment of diabetes guided by the theory of network disease, which deepened the participants' understanding of the treatment of diabetes in traditional Chinese medicine.

Network disease theory guides the treatment of diabetes to highlight the intervention strategy of "modulation"

"Diabetes and its complications, which Chinese medicine calls thirst quenching, belong to the category of

The theory of network disease highlights the intervention strategy of "adjustment", believing that "adjustment" is different from confrontation and alternative treatment, including adjusting camp guards, qi and blood, yin and yang, adjusting the qi of the five viscera, gasification of qi machine, evil and good, and harmonious balance of the internal and

Guided by the theory of network disease, the proprietary Chinese medicine Jinlida granules formed from the spleen therapy have the effect of protecting pancreatic islet β cells, reducing insulin resistance, and regulating glycolipid metabolism, which is suitable for patients

The "Jinguani Program" is a model for the combination of East and West in the treatment of diabetes

Traditional Chinese medicine has been widely used in the whole cycle and process of diabetes prevention and treatment, and in the future, under the diabetes prevention and treatment system led by modern Western medicine, a clinical diagnosis and treatment system with complementary advantages of traditional Chinese medicine and Western medicine should be established to highlight the unique advantages

Professor Lian Fengmei of Guang'anmen Hospital of China Academy of Chinese Medical Sciences introduced that a clinical study led by Academician Tong Xiaolin included a total of 192 patients with type 2 diabetes whose blood glucose was poorly controlled after 3 months

Professor Lian Fengmei stressed that Jinlida is a model for the treatment of diabetes in traditional Chinese medicine, which has both reliable clinical efficacy and evidence-based medical evidence, so that doctors can use

Brown fat may become a new target for the treatment of obesity and diabetes

The 2017 and 2020 editions of the Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes released by the Diabetes Branch of the Chinese Medical Association have added a chapter on the treatment of

Professor Chen Li, deputy director of the Diabetes Branch of the Chinese Medical Association and Qilu Hospital of Shandong University, introduced that brown fat can promote glucose uptake and improve glucose metabolism; Promotes triglyceride clearance, improves blood lipids; Increase energy expenditure and reduce weight

A series of basic studies have shown that Zinida granules can activate brown fat cell formation, increase mitochondrial content and respiratory function in cells, and thus increase the activity of brown adipose

Dyslipidemia interacts with insulin resistance

The pathogenesis of diabetes is complex, and elevated blood sugar is only the tip of the iceberg, and its potential factors include insulin resistance, oxidative stress, dyslipidemia, and hypertension
.
Professor Song Guangyao, director of the Institute of Endocrine Metabolic Diseases of Hebei Province and the Department of Endocrinology of Hebei Provincial People's Hospital, pointed out that the interaction between blood lipid disorders and insulin resistance is the central link of diabetes and vascular lesions
.

Insulin resistance is an important pathological mechanism of diabetes, but there are currently fewer
Western drugs that improve insulin resistance.
Professor Song Guangyao pointed out that the TCM pathogenesis of insulin resistance is mainly related to spleen loss of good luck, liver qi depression and kidney qi deficiency, and the treatment mainly starts from activating blood stasis, improving qi and strengthening the spleen, nourishing yin and clearing heat, liver detoxification and phlegm dehumidification, and there are many single drugs or compound proprietary drugs that are effective
against insulin resistance.

Professor Song Guangyao introduced that under the guidance of network disease theory, Jinlida granules can intervene in diabetes
from multiple targets such as improving insulin sensitivity, antioxidant factor activity, reducing inflammatory factors, and inhibiting glucagon secretion.
Both basic and clinical case-control studies of Zinlita granules have confirmed that they can improve diabetic insulin resistance by regulating glycolipid metabolism, thereby controlling blood sugar
more effectively.

Improving blood sugar fluctuations is a new idea in the treatment of diabetes

Professor Pan Jiemin of the Department of Endocrinology of Shanghai Sixth People's Hospital said that blood glucose fluctuations are closely related to
the occurrence and development of chronic complications of diabetes.
In terms of macrovascular complications, blood glucose fluctuations are significantly correlated with the severity of coronary heart disease in patients, and their role is independent of the blood glucose level itself; In terms of microvascular complications, blood glucose fluctuations are associated
with urinary microalbumin excretion and diabetic retinopathy.
Therefore, blood glucose management should improve glycosylated hemoglobin and prevent hypoglycemia at the same time, but also improve blood glucose fluctuations, a three-pronged approach
.

"Glucose Target Range Time (TIR) is a new indicator of blood glucose fluctuations that is gaining traction, and many guidelines agree to include it in glycemic control goals as an important glucose monitoring indicator
.
" Professor Pan Jiemin introduced the clinical study on the effect of Jinlida granules on blood glucose fluctuations in patients with type 2 diabetes, led by Academician Jia Weiping of the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, and the results showed that Jinlida granules could significantly improve the patient's glucose metabolism (glycosylated hemoglobin, fasting blood glucose, postprandial blood glucose) and TCM symptom score
.
Compared with the control group, the standard deviation of blood glucose levels in the Zinida granule group was significantly reduced after treatment (-0.
39 vs.
0.
11, P<0.
01), and the TIR of patients in the Zinida granule group increased from 55% before treatment to 79%<b12> after treatment.
Zinca granules have been shown to improve glycemic control and blood glucose fluctuations
in patients with new-time type 2 diabetes.

The purpose of lowering diabetes is to reduce diabetic complications

A 70-year-old female patient with a history of diabetes for 3 years, a history of coronary heart disease and hypertension for 10 years, and the blood glucose control of metformin is not good
.
In November 2021, the local hospital recommended that patients be treated
with insulin.
After that, the patient has symptoms of hypoglycemia such as palpitation and sweating, 2 to 3 times a
day.
In January 2022, chest tightness, breath holding, and anterior anterior pain were diagnosed with acute inferior myocardial infarction, and blood glucose was 2.
8 mmol/l
at the time.

"When the patient came to me for treatment, he had large vascular complications and felt very heartache
.
" Professor Xu Chun of the Third Medical Center of the PLA General Hospital stressed that the problem of hypoglycemia in hypoglycemic reduction must be paid attention to, and every doctor must be clear that the purpose of hypoglycemic reduction is to reduce diabetic complications
.

In view of the occurrence of chronic complications of diabetes, Professor Xu Chun pointed out that excess nutrition will inhibit the AMPK signaling pathway, block catabolism, and activate the mTORC1 signaling pathway to promote anabolic metabolism
.
Long-term anabolic excesses can lead to obesity, diabetes, cardiovascular and cerebrovascular diseases, and tumors
.

Metformin activates the AMPK pathway, inhibits the mTORC1 signaling pathway, improves energy metabolism imbalances, and brings cardiovascular benefits
to patients.
Professor Xu Chun pointed out that in recent years, studies have found that Jinlida particles inhibit the PI3K-Akt-mTOR pathway by acting on the site upstream of PI3K, thereby reducing the occurrence
of diabetic complications.

Professor Xu Chun introduced that some domestic clinical studies have also confirmed that Jinlida granules can reduce the thickness of urine microalbumin and carotid artery intima, improve motor nerve conduction speed and sensory nerve conduction speed, improve type 2 diabetic non-proliferative retinopathy, and have a good effect
on complications such as diabetic microangiopathy and cardiovascular and cerebrovascular diseases.

"There is some evidence-based medical evidence in the prevention and treatment of microvascular complications of diabetes mellitus, but there is a lack of large sample, multi-center clinical research evidence
.
" Professor Xu Chun said that he is very fortunate that the Endocrinology Branch of the Chinese Medical Association, the Journal of the Chinese Medical Association, and the Editorial Board of the Chinese Diabetes Journal recently launched the "Real-World Project for the Prevention and Treatment of Microvascular Complications in Diabetes"
.
The project will help refine the real-world clinical evidence of Jinlida granules in improving blood glucose fluctuations and delaying microvascular complications in patients with type 2 diabetes, and will further promote its application and promotion in the field of diabetes for the benefit of more diabetic patients
.

Lifestyle intervention + Zinida, reversal of prediabetes

A 42-year-old prediabete patient, diagnosed for half a year, came to the hospital to check fasting blood glucose 6.
5 mmol /l, 2 hours after the meal blood glucose 10.
3 mmol / l, HbA_1c 6.
4%, the patient's main symptoms are dry mouth, emotional anxiety
.
Give health education, diet and exercise guidance along with zinc-up granules
.
After 1 month, the patient's fasting blood glucose returned to 5 to 6 mmol/l, and after a meal, 6 to 7 mmol/l, the symptoms of dry mouth disappeared, and the mood returned to normal
.

Professor Zhao Nengjiang of the First Affiliated Hospital of Xiamen University used his real cases in clinical work to illustrate the experience
of comprehensive management of patients with early diabetes plus traditional Chinese medicine treatment to reverse diabetes.

In the newly released "National Guidelines for the Prevention and Treatment of Diabetes at the Grassroots Level (2022)", a new chapter on "Traditional Chinese Medicine For the Prevention and Treatment of Diabetes" has been added to actively support and encourage the integration of traditional Chinese medicine into the comprehensive prevention and treatment system of diabetes, giving full play to the advantages of holistic view, dialectical argument and treatment, combining physical identification, etc.
, and comprehensively using drugs and non-drugs to carry out comprehensive prevention and treatment
.
Guidelines make it clear that in terms of synergistic glucose control and symptom improvement, it is recommended that patients with type 2 diabetes can use Zinca granules
on the basis of conventional treatment.

summary

In recent years, traditional Chinese medicine has achieved remarkable results in the prevention and treatment of diabetes, and has made achievements
in various fields such as substitution, supplementation, efficiency enhancement and detoxification.
As a model for the treatment of diabetes in traditional Chinese medicine, Jinlida granules have a good performance
in regulating sugar and fat, protecting pancreatic islet β cells, improving insulin resistance, improving blood sugar fluctuations, and converting white fat into brown fat.

As a diabetes treatment drug, Jinlida granules are multi-target attacks, reduce blood glucose at the same time, have a good protective effect on large blood vessels and microvascular diseases, and can improve the prognosis of
patients very well.

Chinese medicine is listed as a chapter separately by many diabetes guidelines, which is a recognition of the strength of traditional Chinese medicine in the treatment of diabetes, and it is also the inevitable result of the increasingly detailed evidence-based evidence, and the entry of Chinese medicine into the mainstream field of diabetes prevention and control is the embodiment
of comprehensive strength.