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Int J Cancer: Polyprezinc can effectively prevent chemotherapy-related oral mucositis in patients receiving hematopoietic stem cell transplantation

 Last Update: 2021-09-03
 Source: Internet
 Author: User

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Oral mucositis is a common disease in patients who have undergone hematopoietic stem cell transplantation (HSCT) after receiving high-dose chemotherapy , which plagues patients
.

Researchers once reported in a single-center retrospective analysis that polyprezinc (PZ) can reduce the incidence of oral mucositis associated with hematopoietic stem cell transplantation

Stem cell prevention

The included patients were randomly assigned to the prevention group and the control group.
The prevention group started to take PZ tablets before chemotherapy, and the control group started to take PZ tablets immediately after the occurrence of grade 2 oral mucositis
.

From the beginning of chemotherapy to 35 days after transplantation, oral mucositis was evaluated daily

As a result, a total of 91 patients were enrolled, and 88 patients (47 in the control group and 41 in the prevention group) met the criteria for data analysis
.

Compared with the control group, the incidence of oral mucositis in the prevention group ≥ grade 2 but not ≥ grade 3 was significantly reduced (44.

In summary, these findings indicate that polyprezinc can effectively prevent chemotherapy-related oral mucositis in patients receiving hematopoietic stem cell transplantation, but has no effect on the outcome of hematopoietic stem cell transplantation

Original source:

Junichi Kitagawa, et al.

Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: A multi-institutional randomized controlled trial in this message

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