Inhibit intestinal inflammation, grape seed extract can

Researchers at the University of ivegilli in Spain have found that a high fat / carbohydrate or Western diet can cause bowel changes A number of recent new studies have confirmed that this diet can change the function of epithelial barrier and intestinal inflammation, and also cause changes in body weight and glucose homeostasis, while grape seed proanthocyanidins extract (GSPE) may protect the intestinal tract from this damage In general, it is believed that intestinal barrier dysfunction is due to the entry of toxins into the intestinal cavity, which can cause local inflammation or enter the blood circulation, and induce systemic inflammation through the release of cytokines According to the data published by molecular nutrition and food research, the intake of procyanidins at medium / high doses can improve intestinal inflammation, oxidative stress and barrier function in mice The middle dose is about 25mg / kg, which is basically consistent with the dose taken by people from dietary supplements, while the high dose (50mg / kg) exceeds the intake dose of dietary supplements In this study, 36 week old rats were fed Western diet for 15 weeks, and then randomly divided into 4 groups, namely control group (0 mg / kg), low dose (5 mg / kg), medium dose 25 mg / kg and high dose 50 mg / kg, and then fed for 3 weeks The researchers detected the activity of myeloperoxidase (MPO) and found that the intestinal inflammation in the control group increased, while that in the grape seed extract group decreased significantly In addition, compared with the control group, the content of active oxygen in the serum of the experimental group decreased significantly The researchers also examined the function of the gut barrier and specifically looked at the "tight junction" (TJ) between intestinal epithelial cells, with one side of the lumen and the other side of cells and tissues In a healthy system, substances in the lumen enter the tissue through cells and control their entry In an unhealthy system, when the tight connection fails, the material in the intestinal cavity can bypass the cells and enter the tissues through the tight connection, which will increase the intestinal permeability, which is often called intestinal leakage In addition, the researchers evaluated whether GSPE can regulate the permeability of intestinal barrier, which can cause intestinal inflammation The results show that there is a negative correlation between tight junction protein and the circulating levels of obesity and triglycerides Although there is no direct causal relationship between the two, it also implies that the increase of obesity will reduce the expression of tight junction components, which is basically consistent with the assumption that obesity and high-fat diet will increase intestinal permeability Considering the importance of healthy intestinal barrier function, dietary intervention can prevent and alleviate obesity related metabolic diseases by regulating intestinal permeability In general, oral grape seed proanthocyanidins extract can regulate intestinal inflammation, oxidative stress and improve intestinal barrier function Based on the results of this study, the researchers pointed out that in the context of obesity, people should extensively explore the effects of nutrition or dietary intervention on intestinal health and intestinal permeability regulation.