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New knowledge
On July 7th, the reporter learned from the University of Science and Technology of China that a joint study by Zhang Zhi, Jin Yan’s research team and the Xu Lin team of the Chinese Academy of Sciences found that inflammation in the early stages of life leads to the development of an individual’s anterior cingulate cortex (ACC) during puberty.
Inflammation in the early stages of life, such as trauma and viral infection during pregnancy or childhood, significantly increases the risk of an individual suffering from affective disorders including depression during adolescence or adulthood, and the mechanism of its occurrence is still unclear
The researchers established an inflammation model by administering lipopolysaccharide to the abdominal cavity during the key time window of brain development in mice, and explored the mode of ACC microglia in response to stress during the development of mice from infancy to adolescence
Further studies have found that when the stress comes, the acute increase in mouse glutamate neuron activity can resist the stress invasion and have a protective effect on the body; however, the continuous stress events during puberty development make it have early inflammation The ACC microglia of mice undergoing frequent activation, through the CX3CR1 signal, mediate the excessive phagocytosis of the dendritic spines of glutamate neurons, thereby forming a long-term maladaptive state, that is, the activity of glutamate neurons is reduced
