Indiana University cancer researchers receive $2.5 million in funding to develop treatments for lung cancer

A researcher from the Indiana University Melvin and Brenn Simon Comprehensive Cancer Center received a five-year, 2.

The research led by Dr.

The human body repairs DNA damage caused by the sun's ultraviolet rays, the toxins in the air, and the chemicals in cigarettes every day

Turchi said: "The new therapies we are developing will treat patients who usually have limited treatment options, including lung cancer caused by smoking

Lung cancer is the leading cause of cancer deaths in men and women, accounting for more than 20% of all cancer deaths

Turchi said: "When we can inhibit the binding of replication protein A to single-stranded DNA under replication pressure, we can induce a large number of cell deaths-this is for cancer, which gives us a window of treatment

The RPA inhibitor developed by IU researchers targets cancer through a mechanism different from other cancer treatments

In addition to the application of lung cancer, Turchi's research team is also exploring RPA inhibitors for the treatment of ovarian cancer

Turchi's laboratory is currently working to transfer research results from the cancer research laboratory to clinical patients, based on decades of research on these pathways

Turchi said: "Our current work is not so much discovery, as it is implementation and translation work driven by clinical possibilities

For this research, Turchi and Cancer Center researchers established a new collaboration at the core research facility: Jun Wan, Ph.

"The complementary expertise of many cancer center researchers will allow us to answer some really important questions and ultimately affect the lives of patients," he said