In vitro study on the relationship between quantity effect and time effect of dandelion extract in improving insulin resistance
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Last Update: 2014-12-10
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Source: Internet
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Author: User
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Recently, researchers from the Department of Integrative Chinese and Western medicine, Huashan Hospital, Fudan University, published a paper to explore the dose-response and time-response relationship of dandelion extract in improving insulin resistance in vitro It was pointed out that the effect of dandelion extract on improving insulin resistance showed a good relationship between quantity effect and time effect This article was published in the 3rd issue of Journal of Tongji University (Medical Edition) in 2014 Dexamethasone was used to induce 3T3-L1 adipocytes to establish insulin resistance model The blank control group, dexamethasone model group, positive control group (the final concentration of rosiglitazone was 3.4 μ g / ml) and dandelion extract group (the final concentration was 0.1, 0.3, 1, 3, 10, 30 μ g / ml) were set up to observe the change of glucose concentration in different time nodes (24, 48, 72, 96 h) with and without insulin participation Compared with the blank group and the model group, the glucose content of each dose group of dandelion extract decreased with and without insulin, which was time-dependent and dose-dependent.
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