[In-depth analysis] Diagnosis of peripheral neuropathy, just read this one!

Peripheral neuropathy is the result of peripheral nerve damage.

Peripheral neuropathy is the result of peripheral nerve damage.

 

 

Each nerve in the peripheral system has a specific function, so symptoms depend on the type of nerve affected

Each nerve in the peripheral system has a specific function, so symptoms depend on the type of nerve affected

* Sensory nerves that receive sensations from the skin, such as temperature, pain, vibration, or touch

* Motor nerves that control muscle movement

* Motor nerves that control muscle movement

* Autonomic nerves that control blood pressure, heart rate, digestion and bladder functions

* Autonomic digestion that controls blood pressure, heart rate, digestion and bladder functions

The clinical features of peripheral neuropathy are as follows:

The clinical features of peripheral neuropathy are as follows:

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4.

The clinical anatomical locations and types of peripheral neuropathy : The clinical anatomical locations and types of peripheral neuropathy:

 

 

Types of peripheral nerve pathological damage:

Peripheral nerve pathological damage type: Peripheral nerve pathological damage type:

Classification of neuropathy severity:

Neuropathy severity classification: Neuropathy severity classification:

First-degree injury (neurasthenia) : caused by mild damage, traction, complete nerve, local nerve block, no Wallerian degeneration, segmental demyelination, complete recovery (12 weeks)

First-degree injury (neurological apraxia) First-degree injury (neurological apraxia) : caused by mild damage and traction, with complete nerves, local transmission of nerves to block, no Wallerian degeneration, and segmental degeneration.

Secondary injury (axon segment injury) Secondary injury (axon segment injury) : Damage to axon and myelin sheath, Wallerian degeneration at the distal end of the lesion, complete endoneurium, perineum and adventitia, and sprouting of proximal axons, Regeneration, Schwann cell proliferation, guide budding to grow distally, EMG: fibrillation, denervation potential after 2-3 weeks

Tertiary injury : Endometrial injury, accompanied by scars, hinders axon regeneration, regeneration can enter the adjacent endoneurium tube

Tertiary injury Tertiary injury : Endometrial injury, accompanied by scars, hinders axon regeneration, regeneration can enter the adjacent endoneurium tube

Fourth grade injury Fourth grade injury : nerve bundle is damaged, only the outer membrane is retained

Grade 5 injury : complete nerve injury

Grade 5 Injury Grade 5 Injury : Complete nerve injury

Causes of peripheral neuropathy:

Causes of peripheral neuropathy : Causes of peripheral neuropathy:

 

Hematology/biochemical examination/ immunology /molecular medicine examination of peripheral neuropathy :

Peripheral neuropathy hematology / biochemical / immunological science / molecular medicine examination: peripheral neuropathy hematology / biochemical / immunological science / molecular medicine examination: Immune

The value of peripheral nerve pathological diagnosis (nerve and skin biopsy):

Neuropathological around diagnostic value (nerve and skin biopsy) of: peripheral nerve pathology diagnostic value (nerve and skin biopsy) of: diagnosis

* Peripheral neuropathy with specific pathological changes that can be diagnosed by pathology: abnormal interstitial nerves, abnormal nerve axons, abnormal myelin sheaths or Schwann cells, storage diseases, mitochondrial diseases (broken red fibers can be seen in muscle pathology, Electron microscopy shows abnormal mitochondrial structure)

* Peripheral neuropathy with specific pathological changes that can be diagnosed by pathology: abnormal interstitial nerves, abnormal nerve axons, abnormal myelin sheaths or Schwann cells, storage diseases, mitochondrial diseases (broken red fibers can be seen in muscle pathology, Electron microscopy shows abnormal mitochondrial structure)

* No specific pathological changes, pathological changes in the diagnosis support or inspiration: CMT4B, X- linked inheritance and so on CMT

Peripheral nerve disease prevention : peripheral nerve disease prevention : prevention

* Manage underlying diseases

* Manage underlying diseases
.
manage

*The best way to prevent peripheral neuropathy is to control diseases that put you at risk, such as diabetes , alcoholism, or rheumatoid arthritis
.

*The best way to prevent peripheral neuropathy is to control diseases that put you at risk, such as diabetes , alcoholism, or rheumatoid arthritis
.
diabetes

* Choose a healthy life>
.
E.
g:

* Choose a healthy life>
.
E.
g:

-Eat more fruits, vegetables, whole-grain foods and lean protein to keep your nerves healthy
.
Eating meat, fish, eggs, low-fat dairy products and fortified cereals can prevent vitamin B-12 deficiency
.

-Eat more fruits, vegetables, whole-grain foods and lean protein to keep your nerves healthy
.
Eating meat, fish, eggs, low-fat dairy products and fortified cereals can prevent vitamin B-12 deficiency
.

-Exercise regularly
.
If the condition permits, try to exercise at least three times a week, 30 minutes to 1 hour each time;

-Exercise regularly
.
If the condition permits, try to exercise at least three times a week, 30 minutes to 1 hour each time;

-Avoid factors that may cause nerve damage, including repetitive movements, restricted positions, exposure to toxic chemicals, smoking, and alcohol abuse
.

-Avoid factors that may cause nerve damage, including repetitive movements, restricted positions, exposure to toxic chemicals, smoking, and alcohol abuse
.

references:

references:

[1] Crone C et al.
Diagnosis of acute neuropathies.
J Neurol, 2007, 254:1151-1169.

[1] Crone C et al.
Diagnosis of acute neuropathies.
J Neurol, 2007, 254:1151-1169.

[2] Strand NH, et al.
Mechanism of Action of Peripheral Nerve Stimulation.
Curr Pain Headache Rep 2021 May 11;25(7).

[2] Strand NH, et al.
Mechanism of Action of Peripheral Nerve Stimulation.
Curr Pain Headache Rep 2021 May 11;25(7).

[3] Zhou Shuxin, etc.
, Peripheral Neuropathy: Differential Diagnosis and Management.
[J] Chinese Journal of General Medicine, 2010.
12 (13) 12A.

[3] Zhou Shuxin, etc.
, Peripheral Neuropathy: Differential Diagnosis and Management.
[J] Chinese Journal of General Medicine, 2010.
12 (13) 12A.

 

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