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As the team reported in the Aug.
"These findings are part
In recent years, scientists have discovered that astrocytes play a key role
However, the researchers are not yet sure what
In the new study, Allen and colleagues isolated astrocytes and neurons
Alison Caldwell, lead author of the paper, said: "From a basic scientific perspective, there are so many changes in astrocyte protein secretion in these genetic disorders, and more importantly, so many of these changes overlap between diseases, which is fascinating, and to me, it highlights the importance of
There is one molecule that stands out
"The results show that the neuron is producing a lot of IGF, but it can't get where it needs to be because these molecules produced by astrocytes are interfering with it,"
The team further showed that excess Imfbp2 produced by astrocytes is responsible for slowing neuronal growth, while blocking the production of Imfbp2 produced by astrocytes in Rett syndrome promotes neuronal growth
"We still have a long way to go to get this-based treatment in humans, but we think it holds promise
Allen's lab team is planning follow-up studies of other proteins they found in diseased astrocytes, as well as future experiments to better understand Imfbp2
