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IMS 2022 expresses new oral drug Mezigdomide combined with dexamethasone and bortezomib/carfilzomib for the treatment of RRMM with promising prospects

 Last Update: 2022-09-08
 Source: Internet
 Author: User

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65 mg iron day

18 crown 6

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Research methods

Inclusion criteria were: 1.

figure 1

Research result

As of July 18, 2022, 28 patients received MeziVd, 38 patients received MeziVd-1.

figure 2

Grade 3–4 AEs (TEAEs) during hematologic therapy mainly included MeziVd cohort: neutropenia (32.

image 3

The overall response rates (ORR) of the three groups of patients were 67.

Figure 4

Analysis conclusion

MeziVd and MeziKd demonstrated a manageable safety profile and promising efficacy in RRMM patients, and these results support further evaluation of the efficacy and safety of these MEZI combinations in phase III studies
.

Reference source:

Paul Richardson, et al.
Mezigdomide (MEZI; CC-92480) in combination with dexamethasone (DEX) and bortezomib (BORT) or carfilzomib(CFZ) in patients (pts) with relapsed/refractory multiple myeloma (RRMM).
2022IMS.
Abstract# OAB-053.

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