Important research results to interpret cancer cell resistance research new progress!

this article, small compiled the recent scientists in the field of cancer resistance research has made important research results, share to everyone!
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Nat Commun: Uncovering new mechanisms for cancer resistance to survive by feeding dead cancer cells! doi: 10.1038/s41467-020-14928-3 drug resistance has been a major challenge in the fight against cancer, a recent study published in the international journal Nature Communications Scientists from the University of California and other institutions have developed new ways or can overcome barriers to cancer resistance; researchers have revealed a special mechanism that promotes disease cells to obtain nutrients by clearing dead cell fragments, and research or a new target for researchers to help develop anti-cancer strategies.researcher Aimee Edinger said cancer cells need large amounts of nutrients, chemotherapy and other dna-damaged therapies that can drive tumor cells to speed up their cell metabolism to make the necessary repairs to survive and grow, and that targeted DNA metabolism usually takes a while to function, but in almost all patients,
tumors
cells become resistant, making treatment ineffective.
Science: Revealing a new mechanism for multidrug resistance to cancer cells doi: 10.1126/sciadv.aav7416 , researchers at the Korea Institute of Science and Technology (KAIST) have identified a mechanism for acquired resistance to first-line chemotherapy to second-line targeted therapy, which leads to the "domino effect" of cancer resistance.resistance to cancer drugs is usually controlled by chemotherapy and targeted therapy. Unlike chemotherapy that inhibits rapid proliferation of cells, targeted therapy blocks a single cancer-causing pathway that blocks the growth of
tumors
. In many cases, targeted therapy is used as a maintenance therapy or as a second-line use after first-line chemotherapy. In the article, the researchers found an unexpected drug resistance feature that occurs between chemotherapy and targeted therapy. The team further identified a comprehensive mechanism to promote this sequential treatment of drug resistance. The researchers say several clinical cases have shown that targeted treatments are often the least successful in patients who have exhausted all standard treatments. These explanations ignite our hypothesis that the failed response to certain chemotherapy may accelerate the evolution of resistance to other drugs, especially those with specific targets.3.
Science: A new combination of drugs can overcome drug-resistant cancer cellsdoi:10.1126/scisignal.aas8779 cancer cells can adapt to and develop resistance to chemotherapy drugs, making it difficult to eradicate
tumor
. A new study led by researchers at Brigham and Women's Hospital suggests that a combination of three drugs, including a new glucose-6-phosphate dehydrogenase inhibitor, can overcome cross-treatment resistance. The results of the study were published recently in the journal Science Signaling. , the researchers used computational models, in vitro experiments, in vivo animal models, and in vitro models of clinical exosomes, human
tumor
to explore the metabolic processes of chemotherapy drug tolerance. Based on the Warburg effect, a widely accepted example of drug resistance, the researchers observed that cancer cells absorb edipped glucose, causing the glycoenzyme pathway to overwork. But contrary to the Warburg effect, the researchers found increased mitochondrial activity, indicating high cell oxygen consumption.
Nat Commun: Cell pressure ordoi, which promotes cancer cells' tolerance to chemotherapy in therapy: 10.1038/s41467-020-16747-y has many mechanisms associated with chemotherapy resistance, many of which are not currently known to researchers, and in a recent study published in the international journal Nature Communications, scientists from the University of Vienna and others have revealed that molecular stress cells are being treated by studying the mechanisms that promote chemotherapy.researchers say this so-called cellular stress response plays a key role in the occurrence of multiple diseases and the body's resistance to chemotherapy, and a set of
genetic
processes that promote cell survival in stress conditions;
Sci Adv: The molecular mechanisms that reveal cancer cells' resistance to drugs doi: 10.1126/sciadv.aaz4126 recently published in the international journal Science Advances, "Mre11 In a study by exonuclease activity y sy removes the chain-terminating nucleoside datgemcitabine from the nascent strand ed DNA" study, scientists from the University of Bangor and others have delved into the molecular mechanisms by which the host body is resistant to cancer drugs.many cancer drugs kill cancer cells by inhibiting DNA replication, one of which is Gemcitabine, which can be used to treat pancreatic, bladder and lung cancer, and Gixithabin can simulate the basic elements of DNA, nucleosidede deoxycydine, which competes to integrate cancer cells into DNA, which, once integrated, inhibits the replication of cancer cells. Researcher Hartsuiker said a special protein called Mre11 can remove gixitebin from DNA, which promotes the continued replication of cancer cells, which may explain a new type of ghetlythain resistance mechanism that exists in cancer cells.. Photo Credit: Guilherme de Oliveira 6
Science: How do cancer cells produce therapeutic tolerance? : 1126/science.au8768a breakthrough study published in the journal Science recently showed that cancer cells can create tolerance against cancer treatment by activating the "error-prone DNA replication" pathway.
bacteria
also produce
antibiotics
resistance through the use of a similar process, called stress mutagenesis.human cells are dividing, each time requiring high-precision replication of all DNA sequences to ensure cell survival. The researchers found that this was not the case with cancer. In this study, a team led by Professor David Thomas of the Garvan Institute of Medicine showed how many different types of cancer, including melanoma, pancreatic cancer, sarcoma and
breast cancer
, can make a lot of mistakes when copying DNA after cancer treatment and ultimately lead to drug resistance. Drug resistance can be said to be the main problem facing patients with advanced cancer, and even effective treatments can eventually fail. We have identified basic survival strategies for cancer cells to develop resistance, which provides us with new possible treatment strategies.
J Med Chem: A new strategy or aof resistance to targeted therapies from cancer cells: 10.1021/acs.jmedchem.9b01709 , published in the international journal In a study published in The Journal of Medicinal Chemistry, scientists from the Institute of Cancer Research in London and others have developed a new way to suppress the HSP72 protein, which is important to help cancer cells survive and resist therapies, and the findings are expected to help researchers discover new cancer drugs that target the protein.more importantly, the researchers also developed a test to determine how effective this new enhanced method is in blocking HSP72 activity compared to earlier methods, and found that the new method is more than 100 times more effective at blocking HSP72 activity than the earlier method. HSP72, or thermokin protein 72, is essential for the survival of cancer cells and is primarily responsible for the instructions of silence to self-destruct cancer cells, and researchers are now struggling to find new drugs that effectively inhibit the function of the HSP72 protein.
Nat Commun: Epigenetic modification of DNA promotes breast cancer tolerance to hormone therapy doi: 10.1038/s41467-019-14098-x tolerance to hormone therapy DNA in breast cancer cells often undergo epigenetic
changes
, hormone therapy is an effective treatment for ER-plus breast cancer, which accounts for 70 percent of all breast cancer patients diagnosed

; reversing these
epigenetic
changes may hopefully help reduce the recurrence rate of breast cancer patients. , scientists from the Gavin Institute of Medicine in Sydney, among others, found that the 3-Dwired structure of DNA in ER-breast cancer cells that are tolerated to hormone therapy may have been "rewired" to alter gene activation and inactivation. Researcher Professor Clark said: 'This study is the first to reveal a key 3-D DNA interaction that is linked to whether breast cancer is sensitive to hormone therapy, clarifying the processes in it that may help reveal the molecular mechanisms of ER-cancer avoidance from hormone therapy, and hopefully help develop new breast cancer therapies.'
iScience: Revealing the resistance to cancer chemotherapy associated with
p53 doi: 10.1016/j.isci.2020.100820 More than half of cancer cases worldwide are associated with the p53 gene mutation, which produces proteins that protect DNA from cancer-induced changes, and when the protein deforms, it not only loses its ability to protect, but also creates new functions. By forming clusters of proteins that may be resistant to chemotherapy, they promote the spread of
tumor
, which researchers do not yet know about the mechanism by which this occurs and how they develop resistance. , in a recent study published in the international journal iScience, scientists from Brazil's National Institute of Structural Biology and Bioimaging Technology identified a large number of "traitor" proteins in chemotherapy-tolerant cells derived from glioblastoma, and researchers revealed how these proteins are deformed to resist therapy, forming larger blocks larger than those in healthy individuals, some of which also have the characteristics of amyloid proteins (when mutations are induced). the use of living cells is critical to research in this area, and in the article, researchers identified small oligomers in living cells, a structure slightly larger than the healthy p53 version, which promotes p53 aggregation and is closer to what happens in the human body. The researchers studied p53-specific mutations (M2371) because raw proteins and other mutations that did not occur did not mediate the same drug tolerance. ,
Neuro-Oncology: Identify a new compound that effectively kills cancer cells that are resistant to chemotherapy doi: 10.1093/neuonc/noz170 a recent study published in the international journal Neuro-Oncology, from Scientists at Hokkaido University and other institutions have identified a special compound that effectively kills glioblastoma-initiating cells that are resistant to chemotherapy, and the results may help develop a low-toxic drug that can cure the
of refractive
tumors. Despite scientists' long-standing efforts to develop new treatments, the prognosis of most patients with glioblastoma, which is a malignant glioma, is a malignant glioma, with a median survival of about 15 months, one of the reasons for the lack of elimination of
cancer