Important progress in the targeting of tumors using nanoparticles

　　Medicine Network December 5, the nanoparticles loaded with identification ligands, the tumor active identification, so as to achieve targeted treatment is an important research direction of tumor treatment, but in recent years the effectiveness of this approach has become more and more questioned The latest research results of Chinese researchers show that the use of nanoparticles to target tumors is effective, but its effect is obviously affected by the target modification model the researchers who carried out the study were Li Feng, a researcher at the Wuhan Institute of Viruses of the Chinese Academy of Sciences, and Zhang Xianen, a researcher at the Institute of Biophysics of the Chinese Academy of Sciences Recently, with the spatial addressability of protein nanocage, and using controlled self-assembly and efficient click chemical reaction, they successfully achieved precise and controllable modification of target ligands on the mini ferritin nanocage, and obtained six nanoparticle models with specific ligand numbers and spatial distribution a series of experiments on cell level sedation and lotus animal models show that no matter what ligand parameters, there are different degrees of contribution to active targeting Further studies show that the target performance differences that these ligand distribution patterns rely on are related to factors such as clustering of target cell surface receptors and related intracellular swallowing and conditioning Li Feng, , said the study will help understand and clarify the controversy in nanomedicine about active targeting, while highlighting the importance of precision functionalization in building bio-nanoprobes and devices The results of the research have recently been published online in the internationally renowned multidisciplinary journal Small.