Important progress in the study of "superbug" inhibition mechanism in Chinese scholars

　　Medical Network March 26 reporter 25 from the China University of Science and Technology was informed that the university's researchers in the "superbug" inhibition mechanism research made important progress The results were published online in the journal Microbiology (mBio) bacteria and antibiotics are like a game of phase-in As a result of antibiotic abuse in recent years, a class of "superbugs" that are resistant to all beta-lactam drugs, including penicillin and cephalosporins, which are commonly used in the clinic, have emerged, with methicillin-resistant Staphylococcus aureus (MRSA) Once infected with this superbug, it can cause severe pneumonia, sepsis, endocarditis and other deep infections, and even life-threatening application inhibitor Targocil is currently considered an effective anti-superbug A team of professors Chen Yuxing, Zhou Congzhao and Sun Linfeng of The Chinese University of Science and Technology have worked together to illustrate the mechanism by which Targocil inhibits this superbug beat the snake seven inches, fighting the "superbug" also needs to first find its "seven inches" where studies have shown that cytolic acid, the main component of the cell wall of Methicillin-resistant Staphylococcus aureus, is one of the key factors causing drug resistance Cytosic acid plays an important role in bacterial fragmentation, biofilm formation, host colonization and bacterial infection The flip enzyme in the synthetic path of cytosic acid is an important target of the new antimicrobial drugs As one of the most promising antibiotic targets, flip enzymes and their inhibitors have become the focus of research Targocil, a small molecule of the pilot compound, has recently been identified as having a better inhibitory effect on this flip enzyme, but its inhibition molecular mechanism is not yet known, which is not conducive to subsequent drug development the research team analyzed the mechanism of flip enzyme transportcell wall icacid and Targocil inhibition mechanism by using the frozen electron lens method, and further determined the precise site of Targocil binding flip enzyme by biochemical experiment stoic and computer simulation, and further verified the molecular mechanism of inhibiting the transport of cytophoacid by flip enzyme results will provide structural basis and theoretical guidance for the design and optimization of new antibiotics against methicillin-resistant Staphylococcus aureus.