Important causative factors for Helicobacter pylori found

, Professor Li Zhaoshen,digestive medicine department, at ChanghaiHospital in Shanghai, screened out the important pathogenic factors of Helicobacter pylori (Hp), cytotoxin-related antigens (CagA) and vachicopic degenerative cytotoxins (VacA)The researchers also proposed a new theory of differences in hp toxicity, and used Hp Recombinant CagA to establish a serological method to detect CagA, and to develop relevant testkitsRelated achievements have been awarded the second prize of the 2007 National Science and Technology ProgressProfessor Li said that the project for Hp toxic factors, complex pathogenic mechanism, clinical diagnosis to be standardized and other issues, carried out a large-scale epidemiological investigation, screening out hp two important pathogenic factors - CagA and AVac, at the same time proved that CagA is the key factor leading to the occurrence of peptic ulcers, but also an important risk factor for the occurrence of stomach cancerThe team found that the positive and toxic rates of CagA, VacA and disease-causing islands of the Hp China strain were high, and the "Chinese characteristics" of Hp were illustratedThe researchers also proposed the Hp classification theory that the Hp strain is classified as toxic (CagA, VacA positive) and non-toxic strain (CagA, VacA negative)The doctrine was widely accepted by the academic community and was cited 407 times by SCIThe researchers used Hp Recombinant CagA to establish a serological method for detecting Hp and developed an immunoprint diagnostic kit that can simultaneously detect serum CagA, VacA and urea enzyme antibodies to determine Hp's toxicityThe technology can cover more than 95% of the domestic clinical testing needs and scientific research needsAt the same time, the researchers based on Hp toxicity selective root treatment, the existing Hp root treatment program to optimize, enhance the relevance and effectiveness of treatment, saving medical resources(Liu Chang)