Impaired immune response can lead to bone resorption in patients with genetic diseases

According to data from the World Health Organization, about a quarter of the world’s population is infected with tuberculosis, but only 5% to 10% of those infected will develop symptoms

Satoshi Okada, Professor of Pediatrics at the Graduate School of Biomedical and Health Sciences at Hiroshima University, said: "Multifocal osteomyelitis-multipoint bone infection-is one of the representative manifestations of MSMD

Now, a team led by Okada has revealed the molecular basis of chronic bone infections in patients with MSMD

Miyuki Tsumura, a pediatric researcher at the Graduate School of Biomedical and Health Sciences at Hiroshima University and the first author, said: “The frequency of multifocal osteomyelitis in patients with multiple osteomyelitis is particularly high.

She pointed out that analysis of osteomyelitis lesions showed an increase in the number of osteoclasts, which are responsible for the absorption of old bone cells during the growth and repair process

The researchers used three osteoclast precursors cultured from bone marrow cells of MSMD patients and healthy volunteers to examine the formation of osteoclasts in the presence or absence of IFN-γ

When IFN-γ was added to healthy cells, the formation of osteoclasts stopped as expected

When it is added to the cells of MSMD patients, the response is weakened-these cells resist the call to stop forming

"These results indicate that in the absence of signaling molecules, IFN-γ-induced inhibition of osteoclast differentiation and bone resorption is impaired, leading to excessive osteoclast proliferation and increased bone resorption at the infection site.

The researchers plan to further study the overproduction of osteoclasts and the role of osteoblasts (cells that produce new bone) to fully describe the molecular mechanism of multifocal osteomyelitis

DOI

10.

Article title

Enhanced osteoclastogenesis in patients with MSMD due to impaired response to IFN-γ