Immuno Cancerl Immunother: Effects of tumor immunotromystology on patients with leukocyte hyperemia

Tumor-related leukaemia (TRL) is associated with poor survivability of various types of cancer, but the microenvironment of TRL-related human tumors has not yet been fully clarifiedHere, we aim to describe the immune microenvironment of TRL-related cancer patientsstudies compared the transcriptional characteristics of tumor tissue (TRLpos) obtained from patients with cervical cancer and the transcriptional characteristics of tumor tissue without TRL (TRLneg)As a substitute for TRL diagnosis, a white blood cell hyperplasia (LS) score was obtained using different genes expressed between TRLpos and TRLneg tumorsThe immunological spectrum of patients with high (LShigh) or low LS scores in the TCGA database was comparedresults showed that there were differences in transcription between TRLpos tumors and TRLneg tumors, showing genes associated with upward radiation resistance and reduced adaptive immune responseIn the TCGA cervical cancer queue (n s 303), patients with high LS had a lower survival rate (P s 0.023) compared to patients with low LSLShigh tumors have higher levels in radiation resistance, wound healing, and myelin-like inhibition (MDSC) markers, M2 macrophages are more immersion, and M1 macrophages and lymphocyte leachate are lowerLShigh tumors also expressed higher CXCR2 towardsther, CSF2, and CSF3In the pan-cancer cohort (n - 9984), LShigh tumors also showed poor survival, characteristics of inhibitory immune microenvironments and higher expression of CXCR2 prosthesis factorsin summary, our data provide evidence for inhibitory immunoimmune microenvironments in Patients of TRL and present promising targets, such as CXCR2 axes, for therapeutic intervention