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Immunity: Scientists reveal the developmental origin of disease-associated microglia and disease-inflammation-associated macrophages

 Last Update: 2022-08-20
 Source: Internet
 Author: User

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Brain macrophage populations include microglia, border-associated macrophages, and monocyte-derived cells, which together control brain development and homeostasis

Figure 1: Multiple omics data reveal sources of BAM

Interestingly, the transcriptomic profile of adult DAM is similar to that of early postnatal integrin CD11c-expressing microglia (Youth-Associated Microglia, YAM), both expressing a large number of genes related to phagocytosis, autophagy, and mitochondrial metabolism

Figure 2: Peripheral-derived DIM is present in Alzheimer's disease model mice

To further understand the role of DIM in the disease, the researchers found that these DIM cell populations mainly aggregated in the hippocampus, meninges, basolateral amygdala, and cortex of Alzheimer's model mice, and were located in the vicinity of amyloid-beta aggregates

Collectively, we demonstrate through multiple omics data that embryonic-derived disease-associated microglia-dependent TREM2 and peripheral bone marrow-derived disease-associated macrophages appear in aging and neurodegenerative diseases

【references】

Immunity (2022), https://doi.

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