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In laboratory animals, reducing calorie intake has been shown to improve health and longevity, and recent research suggests that these benefits may extend to humans as wel.
In a new study, researchers at Yale University show that moderate calorie restriction can reduce the production of a protein called SPARC, which can control harmful inflammation and improve health in older adult.
The study, led by Vishwa Deep Dixit, director of the Yale Center for Aging Research, published earlier this year identified key human health benefits of moderate calorie reductio.
Specifically, Dixit and his colleagues analyzed the trial data to identify those molecules that had a positive effect on calorie reduction and could be targeted for treatmen.
The researchers looked at genetic changes in the participants' adipose tissue one to two years later and found that people who ate fewer calories had higher levels of a protein called SPARC, which secretes cysteine-rich acidic protein.
"Because inflammation plays such an important role in age-related decline, we wanted to better understand whether longevity-friendly interventions like calorie restriction could control inflammation and immune responses through SPARC," Dixit sai.
The researchers found that SPARC triggers inflammation by converting anti-inflammatory immune cells called macrophages into a pro-inflammatory stat.
The finding may help prevent age-related declin.
The authors add: "We now have a better understanding of how SPARC affects the inflammatory and health spans by acting on macrophage.
Provided by Yale University
