IDH1 mutant glioma cells are less sensitive and invasive to radiotherapy

The mutation of isocric acid dehydrogenase 1 (IDH1) was associated with lower invasiveness of diffuse gliomas, increased radiotherapy sensitivity and extended overall survivalJacqueline Kessler, of the Department of Radiotherapy at Martin Luther Medical School in Germany, and others analyzed the effects of the idh1R132Hon the process of cell growth metabolism through in vitro experiments with malignant glioma cell systemsThe results were published in the June 2019 issue of The Cancersresultsin vitro cytological studies show that the expression of idh1R132Henhances the accumulation of radonH2AX residue semothes in the cells induced by radiation, and reduces the amount of glutathione (GSH) and is not associated with the oxygen content around the cellThe expression of the IDH1 mutation leads to a significant increase in cell stability and induces changes in the tissue structure of the cytoskeleton, which directly causes the hardness of the cells to strengthen, and the stable cell structure is not conducive to their division and growth and migrationIn addition, the researchers found through quantitative polymerase chain reaction (qPCR) that the expression of idh1R132Hled to a decrease in the expression of waveform proteins within glioma cells, which are an important component of the cell skeleton and an regulatory factor for cell stabilityThe above results emphasize the important role of IDH1 mutation in the treatment of patients with diffuse glioma, especially to enhance the effectiveness of radiation therapyTherefore, testing the genetic status of IDH1 before treatment can expand the efficacy of immune grouping, accurately distinguishbetween between patients with less invasive and more radiosensitive IDH1 mutant diffuse gliomas and patients with more aggressive IDH1 wild diffuse gliomas, the former may benefit from radiotherapy and personalized intensive therapyconclusionsthe expression of the idh1 R132H significantly increases the cell hardness of high-level glioma cell line; Idh1 R132H malignant glioma cells with mutations had increased radiation sensitivity and reduced invasive biological behavior, consistent with clinical observations of high-level gliomawith with better prognosis Therefore, the prognostic improvement and total survival of glioma patients with idh1 mutations are the interaction of two factors that increase sensitivity to radiation therapy and decrease the invasiveness of tumor cells.