IDH1/2 mutations associated with grade II, II/III and III brain gliomas

IDH1 is located on chromosome 2q33 and encodes the IDH1 enzyme to catalyze the oxidation of isocric acid to alpha-ketone diacid, resulting in the production of pyridine adenine dinucleotide phosphate (NADPH)The study found that idh1 had a high rate of gene mutation in the encoded cytoplasmic NADP-dependent type of gliomaThe IDH2 gene is located at 15q26.1, with the most common mutation being R172KThe IDH2 mutation of R172 also includes R172W and R172MThe IDH 1/2 mutation is associated with prognosis in patients with gliomaLei Deng, graduate school Chinese of Nanchang University School of Medicine, and Lei Deng of neurosurgery at the 94th Hospital of the People's Liberation Army, analyzed the relationship between the IDH1/2 mutation and the classification of glioma, published in the October 2018 issue of Oncol Letttumor tissue is from August 2011 to March 2014, the Third Military Medical University Newbridge Hospital Neurology Department and Nanchang University First Affiliated Hospital Neurology Department of 206 cases of cerebral glial specimensThe average age of the patients was 42.06 to 15.21 years, including 102 males and 104 females158 cases from the Third Military Medical University Xinqiao Hospital, 48 cases from Nanchang University First Affiliated HospitalThe Neurosurgery of the Third Military Medical University of Chongqing provided 9 samples of glioma to spinal cordPatients are graded according to who central nervous system tumor classification criteriaOf the 206 cases, 6 cases of Grade I glioma, 66 cases of Grade II glioma, 26 cases of Grade II-III glioma, 61 cases of Class III glioma, 47 cases of IV-grade glioma (including primary 43 cases, 4 cases of secondary secondary)The patient did not receive radiotherapy, chemotherapy or other treatment before the operationTumor tissue slicing, including 158 frozen specimens and 48 paraffin specimensThe researchers assessed the relationship between patient age and glioma grading and detected and analyzed the idh1/2 mutation of different graded gliomaslevel of glioma increases with the patient's ageThe average age of patients with primary IV-grade glioma was significantly higher than that of Class I and Grade II patients (P 0.05), and the average age of patients with grade II glioma was significantly lower than that of Class III patients (P 0.05) Most of the IDH1/2 mutations in grade II, II-III, and III gliomas occur in adults and rarely seen in adolescents Idh1/2 mutations are most common in stage II, II-III, and III gliomas, with significant differences in mutation frequencies in different levels of glioma (P 0.001) (Table 1) The authors note that the IDH1/2 mutation is associated with the progression of stage II, GRADE II-III, and iii stage gliomas Table 1 The idh1/2 mutation of different graded gliomas.