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Image: Replication of hepatitis C virus (HCV) and hepatitis E virus (HEV) in human hepatocytes
It is well known that hepatitis virus co-infection does exist
A protein can suppress infection
To find out more about co-infection with hepatitis C (HCV) and hepatitis E virus (HEV), the researchers first infected liver cells in cell culture with both pathogens
"The hepatitis C virus is made up of 10 proteins," explains Thomas Burkard, "and by overproducing individual products, we were able to study their effects
Experiments in animal models, however, showed a different pattern: Transgenic mice with human livers could be infected with both viruses
"Here, HCV is not as dominant as in cell cultures," says Thomas Burkard
