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Depression and post-traumatic stress disorder and other emotional disorders are more common in women, while alcohol use disorder (AUD) is more common in men
.
However, in the development of mood disorders and alcohol use disorders caused by chronic stress, female groups are more sensitive
.
More and more women suffer from co-morbidities of mood disorders and alcohol use disorders
.
Continuous stress stimulation will damage the goal-oriented decision-making ability, and there will be continuous maladaptive behavior patterns
.
On May 31, 2021, the Klaus A.
Miczek research team of the Department of Psychology at Tufts University simulated the stress on humans through chronic stress for 10 days and found that this stress induced social disorders and increased vigilance in female mice.
At the same time, it promotes alcoholism in female mice
.
Female mice drinking alcohol increased after stress.
Female mice underwent a continuous 4-week alcohol feeding experiment after 10 days of chronic frustration.
The results showed that after experiencing stress, female mice showed vigilant sexual behaviors and social disturbances.
, In addition to cognitive dysfunction, alcohol consumption has increased, and I feel a little bit more worried by alcohol
.
What is even more surprising is that after a day of abstinence from drinking, the female mice that had been beaten by their peers became more alcoholic.
Did they break the jar? Neurons expressing corticotropin-releasing hormone (CRH) in the paraventricular thalamus (PVT) and medulla oblongata (rILN) brain regions are involved in regulating the body's drinking behavior
.
CRH neurons also play a key role in stress-induced mood disorders
.
Therefore, researchers speculate that CRH neurons may be an important material basis for the co-morbidity of mood disorders and alcohol use disorders
.
As an adaptive defensive behavior, the mouse mother will launch a maternal attack to protect her offspring from strange invaders
.
Except for these key stages of maternal behavior, female mice rarely initiate aggressive behaviors
.
However, female mice became more aggressive after chronic stress and became more sensitive to unfamiliar mice
.
Through immunofluorescence experiments, it was found that the proportion of CRH neurons in the anterior central medial thalamus (aCMT) of female mice decreased after chronic stress
.
Subsequently, light-suppressive virus and light-activated virus were injected into the brain area, which can reduce the social behavior of female mice and promote aggressive behavior after inhibiting CRH neurons
.
The activation of CRH neurons can alleviate social barriers caused by chronic stress and reduce aggressive behavior
.
Without affecting water consumption, light-activated CRH neurons can significantly inhibit alcoholism caused by abstinence, and can also reduce alcohol consumption in normal mice and female mice after chronic stress
.
These results indicate that CRH neurons in the aCMT brain region simultaneously regulate social behavior, aggressive behavior, and alcohol consumption behavior
.
In general, this article simulates the poorly adaptive behaviors of women under continuous stress through animal models, revealing that the CRH neurons in the front of the central medial thalamus are the key neurons for mood disorders to promote alcohol use
.
[References] 1.
https://doi.
org/10.
1016/j.
biopsych.
2021.
05.
022.
Depression and post-traumatic stress disorder and other emotional disorders are more common in women, while alcohol use disorder (AUD) is more common in men
.
However, in the development of mood disorders and alcohol use disorders caused by chronic stress, female groups are more sensitive
.
More and more women suffer from co-morbidities of mood disorders and alcohol use disorders
.
Continuous stress stimulation will damage the goal-oriented decision-making ability, and there will be continuous maladaptive behavior patterns
.
On May 31, 2021, the Klaus A.
Miczek research team of the Department of Psychology at Tufts University simulated the stress on humans through chronic stress for 10 days and found that this stress induced social disorders and increased vigilance in female mice.
At the same time, it promotes alcoholism in female mice
.
Female mice drinking alcohol increased after stress.
Female mice underwent a continuous 4-week alcohol feeding experiment after 10 days of chronic frustration.
The results showed that after experiencing stress, female mice showed vigilant sexual behaviors and social disturbances.
, In addition to cognitive dysfunction, alcohol consumption has increased, and I feel a little bit more worried by alcohol
.
What is even more surprising is that after a day of abstinence from drinking, the female mice that had been beaten by their peers became more alcoholic.
Did they break the jar? Neurons expressing corticotropin-releasing hormone (CRH) in the paraventricular thalamus (PVT) and medulla oblongata (rILN) brain regions are involved in regulating the body's drinking behavior
.
CRH neurons also play a key role in stress-induced mood disorders
.
Therefore, researchers speculate that CRH neurons may be an important material basis for the co-morbidity of mood disorders and alcohol use disorders
.
As an adaptive defensive behavior, the mouse mother will launch a maternal attack to protect her offspring from strange invaders
.
Except for these key stages of maternal behavior, female mice rarely initiate aggressive behaviors
.
However, female mice became more aggressive after chronic stress and became more sensitive to unfamiliar mice
.
Through immunofluorescence experiments, it was found that the proportion of CRH neurons in the anterior central medial thalamus (aCMT) of female mice decreased after chronic stress
.
Subsequently, light-suppressive virus and light-activated virus were injected into the brain area, which can reduce the social behavior of female mice and promote aggressive behavior after inhibiting CRH neurons
.
The activation of CRH neurons can alleviate social barriers caused by chronic stress and reduce aggressive behavior
.
Without affecting water consumption, light-activated CRH neurons can significantly inhibit alcoholism caused by abstinence, and can also reduce alcohol consumption in normal mice and female mice after chronic stress
.
These results indicate that CRH neurons in the aCMT brain region simultaneously regulate social behavior, aggressive behavior, and alcohol consumption behavior
.
In general, this article simulates the poorly adaptive behaviors of women under continuous stress through animal models, revealing that the CRH neurons in the front of the central medial thalamus are the key neurons for mood disorders to promote alcohol use
.
[References] 1.
https://doi.
org/10.
1016/j.
biopsych.
2021.
05.
022.
