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HUAN BRAIN MAPPING: Structural connectivity-functional connectivity coupling predicts sound therapy outcomes in patients with idiopathic tinnitus

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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journal neuroscience research

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Tinnitus is an auditory hallucination that is felt in the ear in the absence of any external stimulus
.

It severely affects the patient's life and is accompanied by various problems such as difficulty concentrating and listening, anxiety and depression, and even has a major impact on the patient's family, work performance and society

Tinnitus is an auditory hallucination that is felt in the ear in the absence of any external stimulus

Qian Chen et al.

Prospective diffusion tensor imaging and resting-state functional magnetic resonance imaging (fMRI) scans were performed on 60 patients with idiopathic tinnitus and 57 healthy controls
.

Structural connectivity (SC), functional connectivity (FC), and SC-FC coupling were analyzed by graph-theoretical network analysis and correlation analysis between clinical manifestations and graph-theoretical features

Prospective diffusion tensor imaging and resting-state functional magnetic resonance imaging (fMRI) scans were performed on 60 patients with idiopathic tinnitus and 57 healthy controls

Brain Connectivity Matrix Based on Brain Network Volume Atlas

There were 28 cases in the effective group (EG group) and 32 cases in the ineffective group (IG)
.

For FC, the local efficiency of the EG group was higher than that of the IG group

There were 28 cases in the effective group (EG group) and 32 cases in the ineffective group (IG)

Normalized eigenpath length, eigenpath length and overall efficiency were lower in SC, EG and IG patients than in HC group

More importantly, the IG group had a higher degree of coupling than the HC group, while there was no difference in the degree of coupling between the EG and HC groups

The small-world nature of functional and structural network connections
.

Furthermore, there was a significant correlation between SC characteristics and clinical manifestations in EG patients
.

There was a significant correlation between SC features and clinical manifestations in EG patients

Correlations between structural network properties and clinical variables in tinnitus patients
.

Our findings suggest that tinnitus patients exhibit significant changes in the topology of brain networks, especially structural brain networks
.
More importantly, patients with different therapeutic effects showed obvious SC-FC topological coupling properties
.
SC-FC coupling can be used as an indicator to predict the prognosis of patients with idiopathic tinnitus before sound therapy
.
Patients with tinnitus exhibit significant changes in brain network topology, especially structural brain networks
.
More importantly, patients with different therapeutic effects showed obvious SC-FC topological coupling properties
.
SC-FC coupling can be used as an indicator to predict the prognosis of patients with idiopathic tinnitus before sound therapy
.
Patients with tinnitus exhibit significant changes in brain network topology, especially structural brain networks
.
More importantly, patients with different therapeutic effects showed obvious SC-FC topological coupling properties
.
SC-FC coupling can be used as an indicator to predict the prognosis of patients with idiopathic tinnitus before sound therapy
.

original source

Distinct brain structural-functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy.
Qian Chen.
First published: 25 March 2022.
https://doi.
org/10.
1002/hbm.
25848

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