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Hu Guohong's research group from the Institute of Nutrition and Health discovered a new mechanism for the regulation of bone metastasis of lung cancer

 Last Update: 2022-09-07
 Source: Internet
 Author: User

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On August 25, 2022, the international academic journal Journal of Clinical Investigation published online the latest research paper titled "IL20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer" by Hu Guohong's research group from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences

Bone is the most frequently metastatic target organ of solid tumors including breast cancer, lung cancer, and prostate cancer, and bone metastases cause fractures, pain, and even death of patients.

Hu Guohong's research group found in the study that under the stimulation of tumor cells, osteoclasts can secrete the cytokine IL19, thereby promoting the proliferation of lung cancer cells expressing the IL19 receptor IL20RB, leading to the occurrence of bone metastasis

Dr.

Paper link: https://doi.

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