How to use special small molecules to enhance the function of the host's own immune system to resist the occurrence of a variety of infectious diseases?

September 23, 2020 // -- Infections pose a significant health risk to hospitalized patients, and recently, scientists from institutions such as the Fraunhofer Institute of Interface Engineering and Biotechnology have developed a new therapeutic strategy that can improve cell resistance to harmful microorganisms by acting on the body's immune receptors.
Photo Source: Fraunhofer IGB Hospitalization can also pose potential health risks due to the risk of infection posed by pathogens, and for patients who are weak or recovering from surgery, additional infections can lead to serious complications; Candide genus or aspergillus fungus brought about by invasive infections, Candina often appear in the form of biofilms such as catheters and other medical equipment, and traditional treatment methods are often not specific enough, and in the design of drug-resistant microorganisms in the presence of the situation may be far from effective.
Now researchers are using the human body's immune system as their primary defense line to develop faster, more targeted, and infection-fighting strategies, introducing molecules similar to pathogen structures into the reporting cell line to trigger immune-like responses, and speculate that if the immune system can respond to these molecules, it may be effective in responding to real pathogens.
The logic and significance of this approach may seem clear, but it is by no means a simple process, and the difficulty is that by sequencing thousands of molecules to find the molecules that trigger a reaction to the reported cell line, the researchers first used computer chemistry screening techniques to identify molecules that could be potential candidates, a method commonly used in medical research to investigate and simulate the properties and structures of molecules in computers. In the second, the researchers will chemically synthesize molecules that were previously virtually modeled only on a computer in the lab, and in the third, the researchers will place the substances in a solution and add them one by one to a specific cell line summary, allowing the researchers to determine which substances the cells react to throughout the test, while the cell's immune body activates the reported gene, triggering a color response.
Photo Source: Fraunhofer IGB's in-body tests of molecules that cause a reaction go to the next stage of in-body testing, in which the researchers repeat the experiment, but this time using not the cell line, but human blood and immune cells isolated from the blood, allowing the researchers to determine whether immune bodies in natural cells also respond to immunomodulants.
, the researchers used a variety of methods, including animal models, to test whether the molecules found had an effect on induced fungal infections.
researcher Steffen Rupp said: 'Now that we have reached the first important milestone, we have found that specific molecules can significantly affect the immune response in human blood and reduce the severity of fungal infections in mice.'
If such treatments are successfully developed and approved, and eventually commercialized, clinicians will build on existing treatments with a new weapon against hospital infections.
Finally, the researchers say we hope the new treatment will one day help fight fungal infections and help fight other infectious diseases or inject autoimmune diseases such as arthritis and psoriasis.
() References: The immune system with small productsby Claudia Vorbeck, Fraunhofer-GesellschaftInfections pose for an increased risk to the patients. In collaboration with a number of of partners, the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB has developeded a new therapeutic approach as part of the InnateFun project. Their strategy is to improve cells' ability to defend them againselvesst harmful microorganisms by acting on their immune receptors. The researchers' work on this therapeutic approach has reached the animal model stage. Models for printings of fungi of the genus Candida, which is is common also in hospitals, were analyzed. The preliminary results are adity. Hospitals are designed to save lives. Yet a hospital stay also poses a potential hazard to people's health due to the risk of ingnes by germs or viruses. For patients who are already in a weakened state or recovering from recent surgery, an additional may lead to serious complications. Invasive printings with fungi of the genus Candida or Aspergillus are particularly feared in hospital settings. Candida is often found as a biofilm on medical devices such as catheters. The weather therapeutic approach-combating thection with drugs designed to kill the pathogens-is often not specific enough and has been on show be included in the case drug-resistant microorganisms...