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A large tablet press refers to a machine that places granular or powdery materials in a die hole and presses them into tablets by a punch
.
However, in the production process of tableting, users often report that the results of tableting are not smooth
.
It is reported that the drug is not crushed enough, the fibrous or elastic drug or oil content is high and the mixing is not uniform, which will lead to the phenomenon of loose tablets
.
It can be overcome by pulverizing the drug through a 100-mesh sieve, selecting a more viscous adhesive, appropriately increasing the pressure of the large tablet press, and adding an oil-based drug absorbent to mix thoroughly
.
The amount of binder or wetting agent is insufficient or improperly selected, so that the particle texture is loose or the particle thickness is unevenly distributed, and the coarse and fine particles are layered
.
It can be overcome by using appropriate binders or increasing the dosage, improving the granulation process, stirring more soft materials, and mixing uniform particles
.
If the water content of the particles is too low, the over-dried particles have greater elasticity, and the drug containing crystal water loses more crystal water during the drying process of the particles, making the particles brittle and easy to loosen
.
Therefore, when granulating, the water content of the granules should be controlled according to different varieties
.
If the granules are too dry, spray an appropriate amount of dilute ethanol (50%-60%), mix well and press into tablets
.
According to the industry, the phenomenon of loose tablets during the tableting process may also be related to the nature of the drug itself
.
For example, although the tablet extruded with high density has a certain hardness, it cannot withstand collision and shaking; the fluidity of the particles is poor, and the particles filled into the die holes are not uniform; or there are larger pieces or particles or fragments that block the scraper.
When the feeder and the feeding port are installed, the filling amount will be affected
.
In addition, the tableting machine will also affect the effect of tableting
.
If the pressure is too low, the length of the punch of the large tablet press is uneven, the speed of the vehicle is too fast, or the particles in the hopper are fed more or less
.
It can be overcome by adjusting the pressure, checking whether the die is complete, adjusting the speed, and adding particles frequently to keep a certain stock in the hopper
.
.
However, in the production process of tableting, users often report that the results of tableting are not smooth
.
It is reported that the drug is not crushed enough, the fibrous or elastic drug or oil content is high and the mixing is not uniform, which will lead to the phenomenon of loose tablets
.
It can be overcome by pulverizing the drug through a 100-mesh sieve, selecting a more viscous adhesive, appropriately increasing the pressure of the large tablet press, and adding an oil-based drug absorbent to mix thoroughly
.
The amount of binder or wetting agent is insufficient or improperly selected, so that the particle texture is loose or the particle thickness is unevenly distributed, and the coarse and fine particles are layered
.
It can be overcome by using appropriate binders or increasing the dosage, improving the granulation process, stirring more soft materials, and mixing uniform particles
.
If the water content of the particles is too low, the over-dried particles have greater elasticity, and the drug containing crystal water loses more crystal water during the drying process of the particles, making the particles brittle and easy to loosen
.
Therefore, when granulating, the water content of the granules should be controlled according to different varieties
.
If the granules are too dry, spray an appropriate amount of dilute ethanol (50%-60%), mix well and press into tablets
.
According to the industry, the phenomenon of loose tablets during the tableting process may also be related to the nature of the drug itself
.
For example, although the tablet extruded with high density has a certain hardness, it cannot withstand collision and shaking; the fluidity of the particles is poor, and the particles filled into the die holes are not uniform; or there are larger pieces or particles or fragments that block the scraper.
When the feeder and the feeding port are installed, the filling amount will be affected
.
In addition, the tableting machine will also affect the effect of tableting
.
If the pressure is too low, the length of the punch of the large tablet press is uneven, the speed of the vehicle is too fast, or the particles in the hopper are fed more or less
.
It can be overcome by adjusting the pressure, checking whether the die is complete, adjusting the speed, and adding particles frequently to keep a certain stock in the hopper
.
